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    marc-2 RING-CH-type domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 183961, updated on 9-Dec-2024

    Summary

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    Official Symbol
    marc-2
    Official Full Name
    RING-CH-type domain-containing protein
    Primary source
    WormBase:WBGene00008433
    Locus tag
    CELE_D2089.2
    See related
    AllianceGenome:WB:WBGene00008433
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in protein polyubiquitination. Predicted to be located in membrane. Orthologous to human MARCHF1 (membrane associated ring-CH-type finger 1) and MARCHF2 (membrane associated ring-CH-type finger 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See marc-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    3
    Sequence:
    Chromosome: II; NC_003280.10 (10660225..10660992, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Small nuclear ribonucleoprotein associated homolog 13 Neighboring gene ncRNA Neighboring gene putative splicing factor, arginine/serine-rich 7 Neighboring gene Cysteine-rich DPF motif domain-containing protein 1 Neighboring gene Secreted protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Influences of HLH-2 stability on anchor cell fate specification during Caenorhabditis elegans gonadogenesis. Benavidez JM, et al. G3 (Bethesda), 2022 Apr 4. PMID 35134193, Free PMC Article
    2. trim-21 promotes proteasomal degradation of CED-1 for apoptotic cell clearance in C. elegans. Yuan L, et al. Elife, 2022 Aug 5. PMID 35929733, Free PMC Article
    3. Ubiquitin-mediated pathways in C. elegans. Kipreos ET. WormBook, 2005 Dec 1. PMID 18050424, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein polyubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RING-CH-type domain-containing protein
    NP_496302.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      10660225..10660992 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063901.4 → NP_496302.2  RING-CH-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496302.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18997
      Conserved Domains (1) summary
      smart00744
      Location:24 → 72
      RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins
    Nucleotide Protein
    Heading Accession and Version

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