atx-2 Ataxin-2 homolog;Sm domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: atx-2
Official Full Name: Ataxin-2 homolog;Sm domain-containing protein
Primary source: WormBase:WBGene00000231
Locus tag: CELE_D2045.1
See related: AllianceGenome:WB:WBGene00000231
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable mRNA binding activity. Involved in several processes, including microtubule cytoskeleton organization; regulation of cell cycle process; and regulation of gene expression. Located in cytoplasm. Is expressed in body wall musculature; dorsal nerve cord; germ line; gonad; and ventral nerve cord. Used to study autosomal dominant cerebellar ataxia. Human ortholog(s) of this gene implicated in late onset Parkinson's disease and spinocerebellar ataxia type 2. Orthologous to human ATXN2 (ataxin 2) and ATXN2L (ataxin 2 like). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See atx-2 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 12

Sequence:: Chromosome: III; NC_003281.10 (10461389..10468051)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Katanin, kinesin-13, and ataxin-2 inhibit premature interaction between maternal and paternal genomes in C. elegans zygotes.
Title: Katanin, kinesin-13, and ataxin-2 inhibit premature interaction between maternal and paternal genomes in C. elegans zygotes.
atx-2 regulates the mechanistic target of rapamycin (mTOR) pathway, downstream of AMP-activated protein kinase (AMPK) and upstream of ribosomal protein S6 kinase and mTOR complex 1 (TORC1), by its direct association with Rab GDP dissociation inhibitor beta.
Title: Cell size and fat content of dietary-restricted Caenorhabditis elegans are regulated by ATX-2, an mTOR repressor.
ATX-2 functions in translational regulation that is mediated by GLD-1 and MEX-3 proteins.
Title: ATX-2, the C. elegans ortholog of ataxin 2, functions in translational regulation in the germline.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D2045.1 (e-PCR)
- UniSTS:307406

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in astral microtubule organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in astral microtubule organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell cycle	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of temperature stimulus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in detection of temperature stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of mitotic spindle localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female gonad development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in maintenance of centrosome location	IGI Inferred from Genetic Interaction more info	PubMed
involved_in maintenance of centrosome location	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of centrosome duplication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of microtubule nucleation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein localization to centrosome	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of protein localization to centrosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in oocyte fate determination	IGI Inferred from Genetic Interaction more info	PubMed
involved_in oocyte fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in polar body extrusion after meiotic divisions	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of female gonad development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of female gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fertilization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of germ cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of meiosis I	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of mitotic cell cycle, embryonic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitotic cytokinetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitotic spindle elongation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of oocyte development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of oocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to centrosome	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of centrosome duplication	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of germ cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of mitotic cell cycle, embryonic	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of mitotic cytokinetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of protein localization to centrosome	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of spindle assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in spermatogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in stress granule assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasmic stress granule	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Ataxin-2 homolog;Sm domain-containing protein

NP_001366696.1

Partially confirmed by transcript evidence

NP_001367113.1

Partially confirmed by transcript evidence

NP_001367186.1

Confirmed by transcript evidence

NP_001367241.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

10461389..10468051

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001379897.1 → NP_001367241.1 Sm domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

B2D6K7, G5ED29, Q5FC83

UniProtKB/TrEMBL

D4PH96

Conserved Domains (3) summary

pfam09606
Location:626 → 807

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam06741
Location:283 → 338

LsmAD; LsmAD domain

pfam14438
Location:126 → 198

SM-ATX; Ataxin 2 SM domain
NM_001379898.1 → NP_001366696.1 Ataxin-2 homolog [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

B2D6K7, G5ED29, Q5FC83

Conserved Domains (3) summary

pfam09606
Location:518 → 699

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam06741
Location:175 → 230

LsmAD; LsmAD domain

pfam14438
Location:18 → 90

SM-ATX; Ataxin 2 SM domain
NM_001379899.1 → NP_001367186.1 Ataxin-2 homolog [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

B2D6K7, G5ED29, Q5FC83

Conserved Domains (3) summary

pfam09606
Location:518 → 699

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam06741
Location:175 → 230

LsmAD; LsmAD domain

pfam14438
Location:18 → 90

SM-ATX; Ataxin 2 SM domain
NM_001379900.3 → NP_001367113.1 Ataxin-2 homolog [Caenorhabditis elegans]

Status: REVIEWED