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    C36E8.4 SH3 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 183279, updated on 9-Dec-2024

    Summary

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    Official Symbol
    C36E8.4
    Official Full Name
    SH3 domain-containing protein
    Primary source
    WormBase:WBGene00007983
    Locus tag
    CELE_C36E8.4
    See related
    AllianceGenome:WB:WBGene00007983
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in positive regulation of JNK cascade; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; and protein ubiquitination. Is expressed in nervous system. Orthologous to human NOSTRIN (nitric oxide synthase trafficking). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See C36E8.4 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    9
    Sequence:
    Chromosome: III; NC_003281.10 (4012336..4015779)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene PSI domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Tubulin beta-2 chain Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    SH3 domain-containing protein
    NP_497805.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      4012336..4015779
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065404.7 → NP_497805.2  SH3 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497805.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18501
      Conserved Domains (2) summary
      cd00174
      Location:485 → 543
      SH3; Src Homology 3 domain superfamily
      cl12013
      Location:47 → 265
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    Nucleotide Protein
    Heading Accession and Version

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