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    mif-4 Macrophage migration inhibitory factor [ Caenorhabditis elegans ]

    Gene ID: 190649, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mif-4
    Official Full Name
    Macrophage migration inhibitory factor
    Primary source
    WormBase:WBGene00003237
    Locus tag
    CELE_Y73B6BL.13
    See related
    AllianceGenome:WB:WBGene00003237
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable cytokine activity and phenylpyruvate tautomerase activity. Predicted to be involved in signal transduction. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mif-4 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    3
    Sequence:
    Chromosome: IV; NC_003282.8 (6335230..6335994, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Protein seu-1 Neighboring gene Biogenesis of lysosome-related organelles complex 1 subunit 2 Neighboring gene PNPLA domain-containing protein Neighboring gene RRM domain-containing protein Neighboring gene DNA ligase ATP-dependent N-terminal domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Macrophage migration inhibitory factor (mif) transcription is significantly elevated in Caenorhabditis elegans dauer larvae. Marson AL, et al. Gene, 2001 Oct 31. PMID 11707322
    2. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phenylpyruvate tautomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Macrophage migration inhibitory factor
    NP_500968.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      6335230..6335994 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068567.2 → NP_500968.1  Macrophage migration inhibitory factor [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500968.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9GUG4
      Conserved Domains (1) summary
      cl00235
      Location:4 → 117
      4Oxalocrotonate_Tautomerase; 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one ...
    Nucleotide Protein
    Heading Accession and Version

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