U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    sma-2 Dwarfin sma-2;MH2 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 176229, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    sma-2
    Official Full Name
    Dwarfin sma-2;MH2 domain-containing protein
    Primary source
    WormBase:WBGene00004856
    Locus tag
    CELE_ZK370.2
    See related
    AllianceGenome:WB:WBGene00004856
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; I-SMAD binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including male anatomical structure morphogenesis; nematode pharynx development; and positive regulation of nematode male tail tip morphogenesis. Predicted to be located in cytoplasm and nucleus. Predicted to be part of heteromeric SMAD protein complex. Is expressed in head; pharynx; reproductive system; and seam cell. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome (multiple); Lynch syndrome; female reproductive organ cancer (multiple); pancreatic cancer; and primary pulmonary hypertension. Orthologous to several human genes including SMAD9 (SMAD family member 9). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See sma-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    11
    Sequence:
    Chromosome: III; NC_003281.10 (8749680..8757089)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene DUF19 domain-containing protein Neighboring gene UDP-galactose translocator 1 Neighboring gene Mitochondrial import receptor subunit tomm-70 Neighboring gene ncRNA Neighboring gene 5'-AMP-activated protein kinase catalytic subunit alpha-1 Neighboring gene Chondroitin sulfate synthase mig-22 Neighboring gene Single-stranded DNA-binding protein, mitochondrial

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Somatic polyploidization and cellular proliferation drive body size evolution in nematodes. Flemming AJ, et al. Proc Natl Acad Sci U S A, 2000 May 9. PMID 10805788, Free PMC Article
    2. Single mammalian cells compensate for differences in cellular volume and DNA copy number through independent global transcriptional mechanisms. Padovan-Merhar O, et al. Mol Cell, 2015 Apr 16. PMID 25866248, Free PMC Article
    3. C. elegans DAF-16/FOXO interacts with TGF-ß/BMP signaling to induce germline tumor formation via mTORC1 activation. Qi W, et al. PLoS Genet, 2017 May. PMID 28549065, Free PMC Article
    4. From receptor to nucleus: the Smad pathway. Baker JC, et al. Curr Opin Genet Dev, 1997 Aug. PMID 9309176
    5. Identification of transforming growth factor-beta- regulated genes in caenorhabditis elegans by differential hybridization of arrayed cDNAs. Mochii M, et al. Proc Natl Acad Sci U S A, 1999 Dec 21. PMID 10611331, Free PMC Article

    See all (79) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Three Smad genes, sma-2, sma-3 and sma-4, are all required for signal transduction, suggesting that the functional complex could be a heterotrimer.
      Title: C-terminal mutants of C. elegans Smads reveal tissue-specific requirements for protein activation by TGF-beta signaling.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables I-SMAD binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in BMP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SMAD protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in anatomical structure morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nematode male tail mating organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode male tail tip morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode pharynx development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of multicellular organism growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of nematode male tail tip morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in post-embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in post-embryonic development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of developmental process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mesodermal cell fate specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of multicellular organismal process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of heteromeric SMAD protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Dwarfin sma-2;MH2 domain-containing protein
    NP_001360602.1
    • Partially confirmed by transcript evidence
    NP_001370321.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      8749680..8757089
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001382944.1 → NP_001370321.1  Dwarfin sma-2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q02329, Q02330
      Conserved Domains (2) summary
      cd10495
      Location:222 → 405
      MH2_R-SMAD; C-terminal Mad Homology 2 (MH2) domain in receptor regulated SMADs
      cl00055
      Location:5 → 130
      MH1; N-terminal Mad Homology 1 (MH1) domain

    2. NM_001372636.2 → NP_001360602.1  MH2 domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IIJ7
      Conserved Domains (1) summary
      cd10495
      Location:68 → 251
      MH2_R-SMAD; C-terminal Mad Homology 2 (MH2) domain in receptor regulated SMADs
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02330.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools