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    Y105E8A.20 Methionine--tRNA ligase, mitochondrial [ Caenorhabditis elegans ]

    Gene ID: 173312, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Y105E8A.20
    Official Full Name
    Methionine--tRNA ligase, mitochondrial
    Primary source
    WormBase:WBGene00013678
    Locus tag
    CELE_Y105E8A.20
    See related
    AllianceGenome:WB:WBGene00013678
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable methionine-tRNA ligase activity. Predicted to be involved in methionyl-tRNA aminoacylation. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 25 and spastic ataxia 3. Orthologous to human MARS2 (methionyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Y105E8A.20 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    9
    Sequence:
    Chromosome: I; NC_003279.8 (14486877..14496560, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene pre-microRNA mir-354 Neighboring gene Small ribosomal subunit protein uS10 Neighboring gene SANT_DAMP1_like domain-containing protein Neighboring gene Tyrosine--tRNA ligase Neighboring gene Uncharacterized protein Neighboring gene C2H2-type domain-containing protein;TFIIIC_sub6 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methionine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methionine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in methionyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in methionyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA aminoacylation for protein translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Methionine--tRNA ligase, mitochondrial
    NP_001129797.1
    • Confirmed by transcript evidence
    NP_740948.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      14486877..14496560 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170952.5 → NP_740948.2  Methionine--tRNA ligase, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_740948.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7Z260, Q8WQA1
      Conserved Domains (1) summary
      PRK11893
      Location:2 → 401
      PRK11893; methionyl-tRNA synthetase; Reviewed

    2. NM_001136325.3 → NP_001129797.1  Methionine--tRNA ligase, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001129797.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3KYC0, Q7Z260
      Conserved Domains (1) summary
      PRK11893
      Location:12 → 519
      PRK11893; methionyl-tRNA synthetase; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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