hrdl-1 E3 ubiquitin-protein ligase hrd-like protein 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: hrdl-1
Official Full Name: E3 ubiquitin-protein ligase hrd-like protein 1
Primary source: WormBase:WBGene00009164
Locus tag: CELE_F26E4.11
See related: AllianceGenome:WB:WBGene00009164
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in endoplasmic reticulum unfolded protein response; protein K48-linked ubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be located in membrane. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytosol and endoplasmic reticulum. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 89. Orthologous to human AMFR (autocrine motility factor receptor). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See hrdl-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 6

Sequence:: Chromosome: I; NC_003279.8 (9793756..9796675)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F26E4.11 (e-PCR)
- UniSTS:309965

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info
enables ubiquitin binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in endoplasmic reticulum unfolded protein response	IBA Inferred from Biological aspect of Ancestor more info
involved_in multicellular organism growth	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein K48-linked ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase hrd-like protein 1

NP_492602.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

9793756..9796675

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_060201.6 → NP_492602.2 E3 ubiquitin-protein ligase hrd-like protein 1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

P90852, P90859

Conserved Domains (3) summary

COG5243
Location:200 → 407

HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]

cd14421
Location:449 → 489

CUE_AMFR; CUE domain found in autocrine motility factor receptor (AMFR) and similar proteins

pfam13639
Location:348 → 388

zf-RING_2; Ring finger domain