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    del-6 Amiloride-sensitive sodium channel [ Caenorhabditis elegans ]

    Gene ID: 179474, updated on 9-Dec-2024

    Summary

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    Official Symbol
    del-6
    Official Full Name
    Amiloride-sensitive sodium channel
    Primary source
    WormBase:WBGene00011891
    Locus tag
    CELE_T21C9.3
    See related
    AllianceGenome:WB:WBGene00011891
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ligand-gated sodium channel activity. Predicted to be involved in sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See del-6 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    7
    Sequence:
    Chromosome: V; NC_003283.11 (10572914..10575454)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene GTP cyclohydrolase 1 Neighboring gene Vacuolar protein sorting-associated protein 54 Neighboring gene ncRNA Neighboring gene Mitochondrial scaffolding protein 1;PDZ domain-containing protein Neighboring gene Enhancer of rudimentary homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Physiological insight into the conserved properties of Caenorhabditis elegans acid-sensing degenerin/epithelial sodium channels. Kaulich E, et al. J Physiol, 2023 May. PMID 36200489, Free PMC Article
    2. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ligand-gated sodium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Amiloride-sensitive sodium channel
    NP_001367018.1
    • Confirmed by transcript evidence
    NP_741622.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      10572914..10575454
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171534.9 → NP_741622.2  Amiloride-sensitive sodium channel [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741622.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MPW0
      Conserved Domains (1) summary
      cl02990
      Location:347 → 484
      ASC; Amiloride-sensitive sodium channel

    2. NM_001380748.1 → NP_001367018.1  Amiloride-sensitive sodium channel [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MPW1
      Conserved Domains (1) summary
      pfam00858
      Location:337 → 484
      ASC; Amiloride-sensitive sodium channel
    Nucleotide Protein
    Heading Accession and Version

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