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    unc-23 BAG domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179272, updated on 9-Dec-2024

    Summary

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    Official Symbol
    unc-23
    Official Full Name
    BAG domain-containing protein
    Primary source
    WormBase:WBGene00006760
    Locus tag
    CELE_H14N18.1
    See related
    AllianceGenome:WB:WBGene00006760
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables ATPase activator activity and heat shock protein binding activity. Acts upstream of with a positive effect on muscle attachment. Located in M band; nucleolus; and striated muscle dense body. Is expressed in several structures, including excretory canal; hypodermis; muscle cell; neurons; and pharynx. Orthologous to human BAG2 (BAG cochaperone 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See unc-23 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    5
    Sequence:
    Chromosome: V; NC_003283.11 (8936359..8939684)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene DUF2726 domain-containing protein Neighboring gene ncRNA Neighboring gene Atrophin-1 multi-domain protein;DUF148 domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of the effects of turning bias on chemotaxis in C. elegans. Pierce-Shimomura JT, et al. J Exp Biol, 2005 Dec. PMID 16326954
    2. Epithelial UNC-23 limits mechanical stress to maintain glia-neuron architecture in C. elegans. Martin CG, et al. Dev Cell, 2024 Jul 8. PMID 38670103,
    3. The C. elegans UNC-23 protein, a member of the BCL-2-associated athanogene (BAG) family of chaperone regulators, interacts with HSP-1 to regulate cell attachment and maintain hypodermal integrity. Rahmani P, et al. Worm, 2015 Apr-Jun. PMID 26435886, Free PMC Article
    4. Chaperone complex BAG2-HSC70 regulates localization of Caenorhabditis elegans leucine-rich repeat kinase LRK-1 to the Golgi. Fukuzono T, et al. Genes Cells, 2016 Apr. PMID 26853528
    5. Chemotaxis by the nematode Caenorhabditis elegans: identification of attractants and analysis of the response by use of mutants. Ward S. Proc Natl Acad Sci U S A, 1973 Mar. PMID 4351805, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Epithelial UNC-23 limits mechanical stress to maintain glia-neuron architecture in C. elegans.
      Title: Epithelial UNC-23 limits mechanical stress to maintain glia-neuron architecture in C. elegans.
    2. Study investigated the role of UNC-23 and HSP-1 on LRK-1 function in C. elegans; results suggest that the UNC-23-HSP-1 chaperone complex regulates LRK-1 localization to the Golgi apparatus and consequently determines the polarized sorting of synaptic vesicle proteins to the axons.
      Title: Chaperone complex BAG2-HSC70 regulates localization of Caenorhabditis elegans leucine-rich repeat kinase LRK-1 to the Golgi.
    3. Data indicate that UNC-23 protein interacts with molecular chaperone Hsc70, whose uncoupling from DNJ-13 protein cures the muscular phenotype.
      Title: The balanced regulation of Hsc70 by DNJ-13 and UNC-23 is required for muscle functionality.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATPase activator activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables adenyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heat shock protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-folding chaperone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_positive_effect muscle attachment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein stabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in M band IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in striated muscle dense body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    BAG domain-containing protein
    NP_001380002.1
    • Confirmed by transcript evidence
    NP_505307.1
    • Confirmed by transcript evidence
    NP_872142.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      8936359..8939684
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072906.7 → NP_505307.1  BAG domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505307.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O61980
      Conserved Domains (2) summary
      smart00264
      Location:370 → 450
      BAG; BAG domains, present in regulator of Hsp70 proteins
      TIGR02168
      Location:275 → 452
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    2. NM_001392570.1 → NP_001380002.1  BAG domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5TKA9
      Conserved Domains (2) summary
      smart00264
      Location:369 → 449
      BAG; BAG domains, present in regulator of Hsp70 proteins
      TIGR02168
      Location:274 → 451
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    3. NM_182342.6 → NP_872142.1  BAG domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_872142.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86S24
      Conserved Domains (2) summary
      smart00264
      Location:311 → 391
      BAG; BAG domains, present in regulator of Hsp70 proteins
      TIGR02168
      Location:216 → 393
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    Nucleotide Protein
    Heading Accession and Version

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