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    acl-4 Phospholipid/glycerol acyltransferase domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180519, updated on 9-Dec-2024

    Summary

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    Official Symbol
    acl-4
    Official Full Name
    Phospholipid/glycerol acyltransferase domain-containing protein
    Primary source
    WormBase:WBGene00018657
    Locus tag
    CELE_F49H12.6
    See related
    AllianceGenome:WB:WBGene00018657
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable acyltransferase activity, transferring groups other than amino-acyl groups. Predicted to be involved in lipid metabolic process. Located in endoplasmic reticulum. Is expressed in several structures, including body wall musculature; hypodermis; intestine; non-striated muscle; and pharynx. Orthologous to human GPAT3 (glycerol-3-phosphate acyltransferase 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See acl-4 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    10
    Sequence:
    Chromosome: X; NC_003284.9 (2066554..2070444, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene MARVEL domain-containing protein Neighboring gene ncRNA Neighboring gene Exostosin domain-containing protein Neighboring gene ncRNA Neighboring gene Thioredoxin domain-containing protein Neighboring gene Transmembrane protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitochondria-type GPAT is required for mitochondrial fusion. Ohba Y, et al. EMBO J, 2013 May 2. PMID 23572076, Free PMC Article
    2. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
    3. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    4. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
    5. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Phospholipid/glycerol acyltransferase domain-containing protein
    NP_508379.1
    • Confirmed by transcript evidence
    NP_508380.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      2066554..2070444 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_075978.5 → NP_508379.1  Phospholipid/glycerol acyltransferase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508379.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N5S8
      Conserved Domains (1) summary
      cd07991
      Location:307 → 516
      LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like

    2. NM_075979.8 → NP_508380.2  Phospholipid/glycerol acyltransferase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508380.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N5S9
      Conserved Domains (1) summary
      cd07991
      Location:97 → 306
      LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like
    Nucleotide Protein
    Heading Accession and Version

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