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    ncbp-1 Nuclear cap-binding protein subunit 1 [ Caenorhabditis elegans ]

    Gene ID: 172345, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ncbp-1
    Official Full Name
    Nuclear cap-binding protein subunit 1
    Primary source
    WormBase:WBGene00018156
    Locus tag
    CELE_F37E3.1
    See related
    AllianceGenome:WB:WBGene00018156
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA cap binding activity and mRNA binding activity. Predicted to be involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Predicted to be part of nuclear cap binding activity complex. Predicted to be active in nucleus. Orthologous to human NCBP1 (nuclear cap binding protein subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ncbp-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    14
    Sequence:
    Chromosome: I; NC_003279.8 (6422061..6425794)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene RING-type domain-containing protein Neighboring gene eLRR (extracellular Leucine-Rich Repeat) ONly Neighboring gene Protein kinase domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure activity relationship and target prediction for ABX464 analogues in Caenorhabditis elegans. Shanley HT, et al. Bioorg Med Chem, 2024 Jan 15. PMID 38134663
    2. Caenorhabditis elegans decapping proteins: localization and functional analysis of Dcp1, Dcp2, and DcpS during embryogenesis. Lall S, et al. Mol Biol Cell, 2005 Dec. PMID 16207815, Free PMC Article
    3. A novel, essential trans-splicing protein connects the nematode SL1 snRNP to the CBC-ARS2 complex. Fasimoye RY, et al. Nucleic Acids Res, 2022 Jul 22. PMID 35736244, Free PMC Article
    4. Alignment of the genetic and physical maps in the dpy-5 bli-4 (I) region of C. elegans by the serial cosmid rescue of lethal mutations. McDowall JS, et al. Mol Gen Genet, 1997 Jun. PMID 9230901
    5. A whole-genome RNAi Screen for C. elegans miRNA pathway genes. Parry DH, et al. Curr Biol, 2007 Dec 4. PMID 18023351, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA cap binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA cap binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in 7-methylguanosine mRNA capping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in RNA metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA export from nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulatory ncRNA-mediated gene silencing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of nuclear cap binding complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear cap binding complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nuclear cap-binding protein subunit 1
    NP_491850.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      6422061..6425794
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059449.7 → NP_491850.2  Nuclear cap-binding protein subunit 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491850.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O01763
      Conserved Domains (3) summary
      smart00543
      Location:28 → 241
      MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
      pfam09088
      Location:307 → 474
      MIF4G_like; MIF4G like
      pfam09090
      Location:492 → 762
      MIF4G_like_2; MIF4G like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O01763.3

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