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    cyp-37A1 CYtochrome P450 family [ Caenorhabditis elegans ]

    Gene ID: 175053, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cyp-37A1
    Official Full Name
    CYtochrome P450 family
    Primary source
    WormBase:WBGene00008499
    Locus tag
    CELE_F01D5.9
    See related
    AllianceGenome:WB:WBGene00008499
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Predicted to be located in membrane. Is expressed in intestine; nervous system; pharyngeal-intestinal valve; pharynx; and rectal gland cell. Human ortholog(s) of this gene implicated in Bietti crystalline corneoretinal dystrophy. Orthologous to human CYP4V2 (cytochrome P450 family 4 subfamily V member 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cyp-37A1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    9
    Sequence:
    Chromosome: II; NC_003280.10 (14013826..14016965, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene TPM domain-containing protein Neighboring gene ncRNA Neighboring gene Serine aminopeptidase S33 domain-containing protein Neighboring gene Serine aminopeptidase S33 domain-containing protein Neighboring gene Carbohydrate sulfotransferase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CYP4V2 fatty acid omega hydroxylase, a druggable target for the treatment of metabolic associated fatty liver disease (MAFLD). Osborne N, et al. Biochem Pharmacol, 2022 Jan. PMID 34798124
    2. Specific regulation of thermosensitive lipid droplet fusion by a nuclear hormone receptor pathway. Li S, et al. Proc Natl Acad Sci U S A, 2017 Aug 15. PMID 28760992, Free PMC Article
    3. Dietary and environmental factors have opposite AhR-dependent effects on C. elegans healthspan. Brinkmann V, et al. Aging (Albany NY), 2020 Dec 13. PMID 33349622, Free PMC Article
    4. Caenorhabditis elegans genomic response to soil bacteria predicts environment-specific genetic effects on life history traits. Coolon JD, et al. PLoS Genet, 2009 Jun. PMID 19503598, Free PMC Article
    5. Eicosapentaenoic acid influences the pathogenesis of Candida albicans in Caenorhabditis elegans via inhibition of hyphal formation and stimulation of the host immune response. Mokoena NZ, et al. Med Microbiol Immunol, 2023 Oct. PMID 37672050, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CYtochrome P450 family
    NP_496939.2
    • Product from WormBase gene class cyp;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      14013826..14016965 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064538.4 → NP_496939.2  CYtochrome P450 family [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496939.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XVA6
      Conserved Domains (1) summary
      pfam00067
      Location:41 → 503
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version

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