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    nstp-10 GDP-fucose transporter;Sugar phosphate transporter domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179342, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nstp-10
    Official Full Name
    GDP-fucose transporter;Sugar phosphate transporter domain-containing protein
    Primary source
    WormBase:WBGene00008237
    Locus tag
    CELE_C50F4.14
    See related
    AllianceGenome:WB:WBGene00008237
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GDP-fucose transmembrane transporter activity and antiporter activity. Predicted to be involved in GDP-fucose import into Golgi lumen and protein O-linked fucosylation. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. Is expressed in intestine; nervous system; and rectal gland cell. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIc. Orthologous to human SLC35C1 (solute carrier family 35 member C1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nstp-10 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    6
    Sequence:
    Chromosome: V; NC_003283.11 (9547602..9549836, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Histone H2A Neighboring gene putative histone H2B 3 Neighboring gene Cold-shock protein Neighboring gene Histone H4 Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Glycosylation genes expressed in seam cells determine complex surface properties and bacterial adhesion to the cuticle of Caenorhabditis elegans. Gravato-Nobre MJ, et al. Genetics, 2011 Jan. PMID 20980242, Free PMC Article
    2. Carbohydrates and glycosylation. Berninsone PM. WormBook, 2006 Dec 18. PMID 18050430, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GDP-fucose transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in GDP-fucose import into Golgi lumen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein O-linked fucosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GDP-fucose transporter;Sugar phosphate transporter domain-containing protein
    NP_001263841.1
    • Confirmed by transcript evidence
    NP_001359746.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      9547602..9549836 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001276912.2 → NP_001263841.1  GDP-fucose transporter [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001263841.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q18747, Q968A5
      Conserved Domains (1) summary
      COG5070
      Location:31 → 325
      VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

    2. NM_001373075.4 → NP_001359746.1  Sugar phosphate transporter domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      D6R8W5
      Conserved Domains (1) summary
      cl26744
      Location:23 → 275
      TPT; Triose-phosphate Transporter family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q968A5.1

    Gene LinkOut

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