U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    cyk-1 WAPL domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 175983, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    cyk-1
    Official Full Name
    WAPL domain-containing protein
    Primary source
    WormBase:WBGene00000872
    Locus tag
    CELE_F11H8.4
    See related
    AllianceGenome:WB:WBGene00000872
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable actin binding activity and small GTPase binding activity. Involved in pronuclear migration. Located in actomyosin contractile ring; cleavage furrow; and cytoplasmic side of plasma membrane. Is expressed in body wall musculature; excretory cell; and germ line. Human ortholog(s) of this gene implicated in autosomal dominant auditory neuropathy 1; autosomal dominant nonsyndromic deafness 1; primary ovarian insufficiency; primary ovarian insufficiency 2A; and sensorineural hearing loss. Orthologous to several human genes including DIAPH1 (diaphanous related formin 1). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See cyk-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    14
    Sequence:
    Chromosome: III; NC_003281.10 (7023642..7029205, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Gamma-aminobutyric acid receptor subunit beta Neighboring gene Cuticle collagen 8 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene NEDD8-activating enzyme E1 catalytic subunit Neighboring gene tRNA-Thr Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The ARP2/3 complex prevents excessive formin activity during cytokinesis. Chan FY, et al. Mol Biol Cell, 2019 Jan 1. PMID 30403552, Free PMC Article
    2. Septins and a formin have distinct functions in anaphase chiral cortical rotation in the Caenorhabditis elegans zygote. Zaatri A, et al. Mol Biol Cell, 2021 Jul 1. PMID 34010018, Free PMC Article
    3. Filament-guided filament assembly provides structural memory of filament alignment during cytokinesis. Li Y, et al. Dev Cell, 2021 Sep 13. PMID 34480876, Free PMC Article
    4. Syncytial germline architecture is actively maintained by contraction of an internal actomyosin corset. Priti A, et al. Nat Commun, 2018 Nov 8. PMID 30410005, Free PMC Article
    5. The cytokinesis formins from the nematode worm and fission yeast differentially mediate actin filament assembly. Neidt EM, et al. J Biol Chem, 2008 Aug 29. PMID 18577519, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CYK-1/Formin activation in cortical RhoA signaling centers promotes organismal left-right symmetry breaking.
      Title: CYK-1/Formin activation in cortical RhoA signaling centers promotes organismal left-right symmetry breaking.
    2. the ARP2/3 complex negatively regulates CYK-1 activity.
      Title: The ARP2/3 complex prevents excessive formin activity during cytokinesis.
    3. PTRN-1 CH domain is required to stimulate CYK-1 to facilitate actin dynamics during endocytic recycling.
      Title: PTRN-1/CAMSAP promotes CYK-1/formin-dependent actin polymerization during endocytic recycling.
    4. Both Cdc12p and CYK-1 bind to pre-assembled actin filaments with low nanomolar affinity, but CYK-1 dissociates 2 orders of magnitude more quickly.
      Title: The cytokinesis formins from the nematode worm and fission yeast differentially mediate actin filament assembly.
    5. protein CYK-1 and the profilin PFN-1 mediate the Arp2/3-independent assembly of cortical microfilaments and are required for cytokinesis in the early embryo
      Title: A Formin Homology protein and a profilin are required for cytokinesis and Arp2/3-independent assembly of cortical microfilaments in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular component organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pronuclear migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actomyosin contractile ring IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cleavage furrow IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    WAPL domain-containing protein
    NP_741210.3
    • Confirmed by transcript evidence
    NP_741211.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      7023642..7029205 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171880.6 → NP_741211.3  WAPL domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741211.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JP75
      Conserved Domains (3) summary
      smart00498
      Location:807 → 1257
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:422 → 630
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:201 → 387
      Drf_GBD; Diaphanous GTPase-binding Domain

    2. NM_171180.5 → NP_741210.3  WAPL domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741210.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KYI3
      Conserved Domains (3) summary
      smart00498
      Location:807 → 1257
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:422 → 630
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:201 → 387
      Drf_GBD; Diaphanous GTPase-binding Domain
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.