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    div-1 DNA polymerase alpha subunit B [ Caenorhabditis elegans ]

    Gene ID: 176439, updated on 9-Dec-2024

    Summary

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    Official Symbol
    div-1
    Official Full Name
    DNA polymerase alpha subunit B
    Primary source
    WormBase:WBGene00001002
    Locus tag
    CELE_R01H10.1
    See related
    AllianceGenome:WB:WBGene00001002
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA binding activity. Predicted to be involved in DNA replication initiation. Predicted to be located in nucleus. Predicted to be part of alpha DNA polymerase:primase complex. Is expressed in gonad; pharynx; vulva; and vulval precursor cell. Orthologous to human POLA2 (DNA polymerase alpha 2, accessory subunit). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See div-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    7
    Sequence:
    Chromosome: III; NC_003281.10 (10245056..10248559, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene EGF-like domain-containing protein Neighboring gene Solute carrier organic anion transporter family member Neighboring gene ncRNA Neighboring gene Coronin-like protein cor-1 Neighboring gene Uncharacterized protein Neighboring gene RFS-1 Interacting Partner

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Werner syndrome protein homolog affects C. elegans development, growth rate, life span and sensitivity to DNA damage by acting at a DNA damage checkpoint. Lee SJ, et al. Development, 2004 Jun. PMID 15115755
    2. Onset of C. elegans gastrulation is blocked by inhibition of embryonic transcription with an RNA polymerase antisense RNA. Powell-Coffman JA, et al. Dev Biol, 1996 Sep 15. PMID 8812143
    3. Reproductive isolation in Caenorhabditis: terminal phenotypes of hybrid embryos. Baird SE, et al. Evol Dev, 2000 Jan-Feb. PMID 11256419
    4. Subunits of the DNA polymerase alpha-primase complex promote Notch-mediated proliferation with discrete and shared functions in C. elegans germline. Yoon DS, et al. FEBS J, 2018 Jul. PMID 29775245, Free PMC Article
    5. emb-5, a gene required for the correct timing of gut precursor cell division during gastrulation in Caenorhabditis elegans, encodes a protein similar to the yeast nuclear protein SPT6. Nishiwaki K, et al. Mol Gen Genet, 1993 Jun. PMID 8391108

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of alpha DNA polymerase:primase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA polymerase alpha subunit B
    NP_499268.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      10245056..10248559 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066867.6 → NP_499268.1  DNA polymerase alpha subunit B [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499268.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q21625
      Conserved Domains (1) summary
      pfam04042
      Location:324 → 531
      DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q21625.3

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