acr-12 AcetylCholine Receptor [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: acr-12
Official Full Name: AcetylCholine Receptor
Primary source: WormBase:WBGene00000051
Locus tag: CELE_R01E6.4
See related: AllianceGenome:WB:WBGene00000051
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables acetylcholine-gated monoatomic cation-selective channel activity. Involved in calcium ion import across plasma membrane and regulation of muscle contraction. Located in synapse. Is expressed in neurons. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; cocaine abuse; congenital myasthenic syndrome (multiple); and lung cancer (multiple). Orthologous to human CHRNA1 (cholinergic receptor nicotinic alpha 1 subunit); CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit); and CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See acr-12 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 12

Sequence:: Chromosome: X; NC_003284.9 (13532853..13536459)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study showed that excitatory and inhibitory motor neurons express distinct populations of ionotropic acetylcholine receptors (iAChRs) requiring the ACR-12 subunit.
Title: ACR-12 ionotropic acetylcholine receptor complexes regulate inhibitory motor neuron activity in Caenorhabditis elegans.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R01E6.4 (e-PCR)
- UniSTS:312016

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables acetylcholine-gated monoatomic cation-selective channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetylcholine-gated monoatomic cation-selective channel activity	IDA Inferred from Direct Assay more info	PubMed
enables acetylcholine-gated monoatomic cation-selective channel activity	IEA Inferred from Electronic Annotation more info
enables extracellular ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in calcium ion import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to stimulus	IEA Inferred from Electronic Annotation more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of membrane potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of muscle contraction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of acetylcholine-gated channel complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: AcetylCholine Receptor

NP_001300370.1

Product from WormBase gene class acr;
Confirmed by transcript evidence

NP_510262.1

Product from WormBase gene class acr;
Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

13532853..13536459

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_077861.6 → NP_510262.1 AcetylCholine Receptor [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_510262.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EDF1

Conserved Domains (3) summary

TIGR00860
Location:14 → 539

LIC; Cation transporter family protein

pfam02931
Location:38 → 264

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:271 → 538

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
NM_001313441.4 → NP_001300370.1 AcetylCholine Receptor [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3ATC5

Conserved Domains (2) summary

pfam02931
Location:1 → 173

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:180 → 447

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region