egl-44 TEA domain-containing protein;Transcription enhancer factor-like protein egl-44 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: egl-44
Official Full Name: TEA domain-containing protein;Transcription enhancer factor-like protein egl-44
Primary source: WormBase:WBGene00001208
Locus tag: CELE_F28B12.2
See related: AllianceGenome:WB:WBGene00001208
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; RNA polymerase II-specific DNA-binding transcription factor binding activity; and transcription coactivator binding activity. Involved in several processes, including generation of neurons; positive regulation of exit from mitosis; and regulation of transcription by RNA polymerase II. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including anterior hypodermis; body wall musculature; ganglia; neurons; and pharynx. Human ortholog(s) of this gene implicated in Sveinsson chorioretinal atrophy. Orthologous to several human genes including TEAD2 (TEA domain transcription factor 2) and TEAD4 (TEA domain transcription factor 4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See egl-44 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 11

Sequence:: Chromosome: II; NC_003280.10 (5928830..5940830)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F28B12.2 (e-PCR)
- UniSTS:309996

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in asymmetric neuroblast division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell cycle	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in embryonic organ development	IBA Inferred from Biological aspect of Ancestor more info
involved_in hippo signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in hippo signaling	IEA Inferred from Electronic Annotation more info
involved_in male mating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in neuron differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of exit from mitosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IPI Inferred from Physical Interaction more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: TEA domain-containing protein;Transcription enhancer factor-like protein egl-44

NP_001343765.1

Confirmed by transcript evidence

NP_001343766.1

Confirmed by transcript evidence

NP_001343767.1

Confirmed by transcript evidence

NP_001343768.1

Confirmed by transcript evidence

NP_001367307.1

Confirmed by transcript evidence

NP_001368664.1

Confirmed by transcript evidence

NP_001370297.1

Confirmed by transcript evidence

NP_495186.3

Confirmed by transcript evidence

NP_741006.3

Confirmed by transcript evidence

NP_741007.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

5928830..5940830

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001356848.3 → NP_001343765.1 TEA domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2C9C3H3

Conserved Domains (2) summary

smart00426
Location:89 → 156

TEA; TEA domain

pfam17725
Location:287 → 483

YBD; YAP binding domain
NM_001356849.3 → NP_001343766.1 TEA domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2C9C3C4

Conserved Domains (2) summary

smart00426
Location:89 → 156

TEA; TEA domain

pfam17725
Location:280 → 476

YBD; YAP binding domain
NM_171850.7 → NP_741007.2 Transcription enhancer factor-like protein egl-44 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741007.2

Status: REVIEWED

UniProtKB/Swiss-Prot

D7SFJ5, D7SFJ6, D7SFJ7, D7SFJ8, D7SFJ9, Q19849, Q86NH3, Q86NH4, Q86NH5, Q86NH6, Q95QI4, Q9GT31

Conserved Domains (1) summary

smart00426
Location:90 → 157

TEA; TEA domain
NM_001356850.3 → NP_001343767.1 TEA domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2C9C2P8

Conserved Domains (2) summary

smart00426
Location:90 → 157

TEA; TEA domain

pfam17725
Location:288 → 484

YBD; YAP binding domain
NM_171007.6 → NP_741006.3 Transcription enhancer factor-like protein egl-44 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741006.3

Status: REVIEWED

UniProtKB/Swiss-Prot

Q19849

Conserved Domains (1) summary

smart00426
Location:75 → 142

TEA; TEA domain
NM_062785.6 → NP_495186.3 Transcription enhancer factor-like protein egl-44 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495186.3

Status: REVIEWED

UniProtKB/Swiss-Prot

Q19849

Conserved Domains (1) summary

smart00426
Location:75 → 142

TEA; TEA domain
NM_001381441.3 → NP_001367307.1 Transcription enhancer factor-like protein egl-44 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (2) summary

smart00426
Location:32 → 99

TEA; TEA domain

pfam17725
Location:230 → 426

YBD; YAP binding domain
NM_001381442.1 → NP_001368664.1 TEA domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2C9C333

Conserved Domains (2) summary

smart00426
Location:32 → 99

TEA; TEA domain

pfam17725
Location:223 → 419

YBD; YAP binding domain
NM_001383853.2 → NP_001370297.1 Transcription enhancer factor-like protein egl-44 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (2) summary

smart00426
Location:15 → 82

TEA; TEA domain

pfam17725
Location:206 → 402

YBD; YAP binding domain
NM_001356852.4 → NP_001343768.1 TEA domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2C9C2W1

Conserved Domains (2) summary

smart00426
Location:15 → 82

TEA; TEA domain

pfam17725
Location:213 → 409

YBD; YAP binding domain