gopc-1 PDZ domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: gopc-1
Official Full Name: PDZ domain-containing protein
Primary source: WormBase:WBGene00014101
Locus tag: CELE_ZK849.2
See related: AllianceGenome:WB:WBGene00014101
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables identical protein binding activity. Predicted to be involved in negative regulation of protein localization to cell surface. Predicted to be active in Golgi apparatus; membrane; and trans-Golgi network transport vesicle. Orthologous to human GOPC (golgi associated PDZ and coiled-coil motif containing). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See gopc-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 10

Sequence:: Chromosome: I; NC_003279.8 (14185628..14196295, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS1-221 (e-PCR)
- UniSTS:241715

ZK849.2 (e-PCR)
- UniSTS:306260

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of protein localization to cell surface	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in trans-Golgi network transport vesicle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: PDZ domain-containing protein

NP_001021877.2

Confirmed by transcript evidence

NP_001021878.2

Confirmed by transcript evidence

NP_001122569.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

14185628..14196295 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001026706.4 → NP_001021877.2 PDZ domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021877.2

Status: REVIEWED

UniProtKB/TrEMBL

O18302

Conserved Domains (2) summary

cd00992
Location:284 → 353

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

TIGR02168
Location:42 → 228

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
NM_001026707.5 → NP_001021878.2 PDZ domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021878.2

Status: REVIEWED

UniProtKB/TrEMBL

Q564T0

Conserved Domains (2) summary

cd00992
Location:282 → 351

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00529
Location:90 → 211

HlyD; HlyD membrane-fusion protein of T1SS
NM_001129097.5 → NP_001122569.1 PDZ domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001122569.1

Status: REVIEWED

UniProtKB/TrEMBL

A5JYY2

Conserved Domains (2) summary

cd00992
Location:260 → 329

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

TIGR02168
Location:18 → 204

SMC_prok_B; chromosome segregation protein SMC, common bacterial type