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    rib-1 Exostosin-1 homolog [ Caenorhabditis elegans ]

    Gene ID: 178080, updated on 9-Dec-2024

    Summary

    Official Symbol
    rib-1
    Official Full Name
    Exostosin-1 homolog
    Primary source
    WormBase:WBGene00004360
    Locus tag
    CELE_F12F6.3
    See related
    AllianceGenome:WB:WBGene00004360
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables enzyme binding activity. Contributes to acetylglucosaminyltransferase activity and glucuronosyltransferase activity. Involved in heparan sulfate proteoglycan biosynthetic process and pharynx development. Part of protein-containing complex. Is expressed in alimentary muscle; alimentary system; hypodermal cell; nervous system; and reproductive system. Used to study hereditary multiple exostoses. Human ortholog(s) of this gene implicated in chondrosarcoma and hereditary multiple exostoses. Orthologous to several human genes including EXTL1 (exostosin like glycosyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See rib-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    10
    Sequence:
    Chromosome: IV; NC_003282.8 (11578792..11583841)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Rho-GAP domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene BEN domain-containing protein Neighboring gene EGF-like calcium-binding domain-containing protein Neighboring gene Trigger_C domain-containing protein Neighboring gene ncRNA

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    contributes_to acetylglucosaminyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to glucuronosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables glycosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    Exostosin-1 homolog
    NP_001293963.1
    • Confirmed by transcript evidence
    NP_502180.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      11578792..11583841
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069779.6NP_502180.1  Exostosin-1 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502180.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4F1W7, O01704, Q9U3J6
      Conserved Domains (1) summary
      pfam03016
      Location:46333
      Exostosin; Exostosin family
    2. NM_001307034.3NP_001293963.1  Exostosin-1 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293963.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061AKX1