unc-78 Actin-interacting protein 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: unc-78
Official Full Name: Actin-interacting protein 1
Primary source: WormBase:WBGene00006810
Locus tag: CELE_C04F6.4
See related: AllianceGenome:WB:WBGene00006810
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables actin filament binding activity. Involved in several processes, including myofibril assembly; regulation of actin polymerization or depolymerization; and regulation of locomotion. Located in myofibril and sarcoplasm. Is expressed in anal depressor muscle; body wall musculature; pharynx; and reproductive system. Orthologous to human WDR1 (WD repeat domain 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See unc-78 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 5

Sequence:: Chromosome: X; NC_003284.9 (3408674..3411615, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results indicate that the actin-regulating activity of UNC-78 in cooperation with ADF/cofilin is essential for its in vivo function to regulate actin filament organization in muscle cells.
Title: Enhancement of actin-depolymerizing factor/cofilin-dependent actin disassembly by actin-interacting protein 1 is required for organized actin filament assembly in the Caenorhabditis elegans body wall muscle.
mutagenesis studies identified five residues that affected the actin depolymerizing factor/cofilin-dependent actin filament disassembly activity
Title: Identification of functional residues on Caenorhabditis elegans actin-interacting protein 1 (UNC-78) for disassembly of actin depolymerizing factor/cofilin-bound actin filaments.
a role in regulation actin dynamics in muscle cells
Title: Actin filament disassembling activity of Caenorhabditis elegans actin-interacting protein 1 (UNC-78) is dependent on filament binding by a specific ADF/cofilin isoform.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C04F6.4 (e-PCR)
- UniSTS:308924

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in locomotion	IBA Inferred from Biological aspect of Ancestor more info
involved_in locomotion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle thin filament assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in muscle thin filament assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of actin filament polymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of actin filament depolymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of locomotion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sarcomere organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in skeletal muscle thin filament assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cortical actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in myofibril	IDA Inferred from Direct Assay more info	PubMed
located_in sarcoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Actin-interacting protein 1

NP_001024356.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

3408674..3411615 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001029185.4 → NP_001024356.1 Actin-interacting protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024356.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q11176, Q86GT5

Conserved Domains (3) summary

cd00200
Location:55 → 352

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:63 → 101

7WD40; WD40 repeat [structural motif]

cl29593
Location:238 → 608

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...