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    best-18 Bestrophin homolog;Bestrophin homolog 18 [ Caenorhabditis elegans ]

    Gene ID: 176436, updated on 9-Dec-2024

    Summary

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    Official Symbol
    best-18
    Official Full Name
    Bestrophin homolog;Bestrophin homolog 18
    Primary source
    WormBase:WBGene00011868
    Locus tag
    CELE_T20G5.4
    See related
    AllianceGenome:WB:WBGene00011868
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable chloride channel activity. Predicted to be involved in chloride transmembrane transport. Predicted to be located in plasma membrane. Predicted to be part of chloride channel complex. Orthologous to human BEST2 (bestrophin 2) and BEST4 (bestrophin 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See best-18 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    7
    Sequence:
    Chromosome: III; NC_003281.10 (10212396..10214830)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene putative clathrin heavy chain 1 Neighboring gene Partner of Y14 and mago Neighboring gene Biogenesis of lysosome-related organelles complex 1 subunit 1 Neighboring gene putative citrate synthase, mitochondrial Neighboring gene DRBM domain-containing protein Neighboring gene Cytochrome c oxidase assembly factor 3 Neighboring gene ATP synthase subunit e, mitochondrial

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    2. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chloride channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chloride transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of chloride channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Bestrophin homolog;Bestrophin homolog 18
    NP_001255067.1
    • Confirmed by transcript evidence
    NP_001255068.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      10212396..10214830
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268138.2 → NP_001255067.1  Bestrophin homolog 18 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255067.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34577
      Conserved Domains (1) summary
      pfam01062
      Location:9 → 314
      Bestrophin; Bestrophin, RFP-TM, chloride channel

    2. NM_001268139.4 → NP_001255068.1  Bestrophin homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255068.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G3MTX5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34577.2

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