cbs-1 Cystathionine beta-synthase cbs-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: cbs-1
Official Full Name: Cystathionine beta-synthase cbs-1
Primary source: WormBase:WBGene00013866
Locus tag: CELE_ZC373.1
See related: AllianceGenome:WB:WBGene00013866
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables cystathionine beta-synthase activity; cysteine synthase activity; and pyridoxal phosphate binding activity. Involved in sulfur compound biosynthetic process. Located in cytoplasm. Is expressed in body wall musculature; hypodermis; intestine; pharyngeal muscle cell; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including cerebral infarction; homocystinuria; hyperhomocysteinemia; malaria; and neural tube defect. Orthologous to human CBS (cystathionine beta-synthase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See cbs-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 10

Sequence:: Chromosome: X; NC_003284.9 (10054275..10057528)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZC373.1 (e-PCR)
- UniSTS:308207

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables cystathionine beta-synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cystathionine beta-synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine synthase activity	IDA Inferred from Direct Assay more info	PubMed
NOT enables heme binding	IDA Inferred from Direct Assay more info	PubMed
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables pyridoxal phosphate binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cysteine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cysteine biosynthetic process from serine	IBA Inferred from Biological aspect of Ancestor more info
involved_in sulfur compound biosynthetic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Cystathionine beta-synthase cbs-1

NP_001257091.1

Confirmed by transcript evidence

NP_001257092.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

10054275..10057528

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001270163.4 → NP_001257092.1 Cystathionine beta-synthase cbs-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001257092.1

Status: REVIEWED

UniProtKB/TrEMBL

H9G2P9

Conserved Domains (1) summary

cl00342
Location:30 → 307

Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
NM_001270162.4 → NP_001257091.1 Cystathionine beta-synthase cbs-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001257091.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EFH8, H9G2P9

Conserved Domains (2) summary

TIGR01137
Location:378 → 703

cysta_beta; cystathionine beta-synthase

cl00342
Location:30 → 307

Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...