kat-1 Acetyl-CoA acetyltransferase homolog, mitochondrial [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: kat-1
Official Full Name: Acetyl-CoA acetyltransferase homolog, mitochondrial
Primary source: WormBase:WBGene00002183
Locus tag: CELE_T02G5.8
See related: AllianceGenome:WB:WBGene00002183
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable acetyl-CoA C-acetyltransferase activity. Located in mitochondrion. Is expressed in body wall musculature; gonad; intestine; pharynx; and tail. Used to study obesity. Human ortholog(s) of this gene implicated in beta-ketothiolase deficiency and carbohydrate metabolic disorder. Orthologous to human ACAT1 (acetyl-CoA acetyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See kat-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 6

Sequence:: Chromosome: II; NC_003280.10 (7073814..7075511)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

defects in fatty acid oxidation can limit lifespan and accelerate aging in C. elegans and that kat-1-mediated fatty acid oxidation is crucial for overexpressed sir-2.1 to delay aging.
Title: 3-Ketoacyl thiolase delays aging of Caenorhabditis elegans and is required for lifespan extension mediated by sir-2.1.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T02G5.4 (e-PCR)
- UniSTS:310616

T02G5.8 (e-PCR)
- UniSTS:310618

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables acetyl-CoA C-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity, transferring groups other than amino-acyl groups	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Acetyl-CoA acetyltransferase homolog, mitochondrial

NP_495455.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

7073814..7075511

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_063054.8 → NP_495455.2 Acetyl-CoA acetyltransferase homolog, mitochondrial [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495455.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q22100

Conserved Domains (2) summary

PLN02644
Location:26 → 407

PLN02644; acetyl-CoA C-acetyltransferase

cd00751
Location:25 → 406

thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...