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    hmit-1.3 Proton myo-inositol cotransporter hmit-1.3 [ Caenorhabditis elegans ]

    Gene ID: 175458, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hmit-1.3
    Official Full Name
    Proton myo-inositol cotransporter hmit-1.3
    Primary source
    WormBase:WBGene00010811
    Locus tag
    CELE_M01F1.5
    See related
    AllianceGenome:WB:WBGene00010811
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable myo-inositol:proton symporter activity. Predicted to be involved in myo-inositol transport and transmembrane transport. Located in apical plasma membrane. Is expressed in head; intestine; and nervous system. Orthologous to human SLC2A13 (solute carrier family 2 member 13). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See hmit-1.3 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    9
    Sequence:
    Chromosome: III; NC_003281.10 (3510962..3516762, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Lipoyl synthase, mitochondrial Neighboring gene Transmembrane protein 245 Neighboring gene ncRNA Neighboring gene Large ribosomal subunit protein bL35m Neighboring gene DDHD domain-containing protein Neighboring gene Large ribosomal subunit protein eL37 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. H+/myo-inositol transporter genes, hmit-1.1 and hmit-1.2, have roles in the osmoprotective response in Caenorhabditis elegans. Kage-Nakadai E, et al. Biochem Biophys Res Commun, 2011 Jul 8. PMID 21679696
    2. RNAi screening for modulators of an osmo-sensitive gene response to extracellular matrix damage reveals negative feedback and interactions with translation inhibition. Chandler LM, et al. PLoS One, 2023. PMID 37155688, Free PMC Article
    3. Transcriptomics of ivermectin response in Caenorhabditis elegans: Integrating abamectin quantitative trait loci and comparison to the Ivermectin-exposed DA1316 strain. Dube F, et al. PLoS One, 2023. PMID 37141255, Free PMC Article
    4. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables myo-inositol:proton symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in myo-inositol transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Proton myo-inositol cotransporter hmit-1.3
    NP_497725.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      3510962..3516762 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065324.7 → NP_497725.2  Proton myo-inositol cotransporter hmit-1.3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497725.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q21455
      Conserved Domains (1) summary
      cl28910
      Location:34 → 558
      MFS; Major Facilitator Superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q21455.3

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