T02G5.7 Acetyl-CoA C-acetyltransferase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: T02G5.7
Official Full Name: Acetyl-CoA C-acetyltransferase
Primary source: WormBase:WBGene00020166
Locus tag: CELE_T02G5.7
See related: AllianceGenome:WB:WBGene00020166
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable acetyl-CoA C-acetyltransferase activity. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in beta-ketothiolase deficiency and carbohydrate metabolic disorder. Orthologous to human ACAT1 (acetyl-CoA acetyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See T02G5.7 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 4

Sequence:: Chromosome: II; NC_003280.10 (7075614..7077188)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T02G5.4 (e-PCR)
- UniSTS:310616

T02G5.7 (e-PCR)
- UniSTS:310617

T02G5.8 (e-PCR)
- UniSTS:310618

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables acetyl-CoA C-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity, transferring groups other than amino-acyl groups	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Acetyl-CoA C-acetyltransferase

NP_495456.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

7075614..7077188

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_063055.5 → NP_495456.1 Acetyl-CoA C-acetyltransferase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495456.1

Status: REVIEWED

UniProtKB/TrEMBL

Q22101

Conserved Domains (2) summary

cd00751
Location:7 → 389

thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...

TIGR01930
Location:8 → 388

AcCoA-C-Actrans; acetyl-CoA acetyltransferases