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    frm-1 FERM domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 173360, updated on 9-Dec-2024

    Summary

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    Official Symbol
    frm-1
    Official Full Name
    FERM domain-containing protein
    Primary source
    WormBase:WBGene00001488
    Locus tag
    CELE_ZK270.2
    See related
    AllianceGenome:WB:WBGene00001488
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable actin binding activity and structural molecule activity. Predicted to be involved in actomyosin structure organization. Located in plasma membrane. Is expressed in several structures, including intestine and pharynx. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 11 and esophagus squamous cell carcinoma. Orthologous to human EPB41L1 (erythrocyte membrane protein band 4.1 like 1) and EPB41L3 (erythrocyte membrane protein band 4.1 like 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See frm-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    15
    Sequence:
    Chromosome: I; NC_003279.8 (14875823..14900322, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ATP-dependent DNA helicase Neighboring gene Olfactomedin-like domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene SSD domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A possible role for FRM-1, a C. elegans FERM family protein, in embryonic development. Choi B, et al. Mol Cells, 2011 May. PMID 21448586, Free PMC Article
    2. The C. elegans VIG-1 and FRM-1 modulate carbachol-stimulated ERK1/2 activation in chinese hamster ovary cells expressing the muscarinic acetylcholine receptor GAR-3. Shin Y, et al. Neurochem Res, 2014 Apr. PMID 24604007
    3. A network of autism linked genes stabilizes two pools of synaptic GABA(A) receptors. Tong XJ, et al. Elife, 2015 Nov 17. PMID 26575289, Free PMC Article
    4. The C. elegans ezrin-radixin-moesin protein ERM-1 is necessary for apical junction remodelling and tubulogenesis in the intestine. Van Fürden D, et al. Dev Biol, 2004 Aug 1. PMID 15242805
    5. The USTC co-opts an ancient machinery to drive piRNA transcription in C. elegans. Weng C, et al. Genes Dev, 2019 Jan 1. PMID 30567997, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytoskeletal protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actomyosin structure organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    FERM domain-containing protein
    NP_001021866.1
    • Confirmed by transcript evidence
    NP_493599.2
    • Confirmed by transcript evidence
    NP_493600.2
    • Confirmed by transcript evidence
    NP_493601.2
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      14875823..14900322 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_061199.6 → NP_493600.2  FERM domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493600.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EEP9
      Conserved Domains (4) summary
      smart00295
      Location:27 → 221
      B41; Band 4.1 homologues
      pfam05902
      Location:4424 → 4528
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:321 → 357
      FA; FERM adjacent (FA)
      cl17171
      Location:216 → 310
      PH-like; Pleckstrin homology-like domain

    2. NM_061200.6 → NP_493601.2  FERM domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493601.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EEG8
      Conserved Domains (4) summary
      smart00295
      Location:27 → 221
      B41; Band 4.1 homologues
      pfam05902
      Location:4542 → 4646
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:321 → 357
      FA; FERM adjacent (FA)
      cl17171
      Location:216 → 310
      PH-like; Pleckstrin homology-like domain

    3. NM_061198.5 → NP_493599.2  FERM domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493599.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFD6
      Conserved Domains (4) summary
      smart00295
      Location:27 → 221
      B41; Band 4.1 homologues
      pfam05902
      Location:528 → 632
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:321 → 357
      FA; FERM adjacent (FA)
      cl17171
      Location:216 → 310
      PH-like; Pleckstrin homology-like domain

    4. NM_001026695.4 → NP_001021866.1  FERM domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021866.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EBP4
      Conserved Domains (4) summary
      smart00295
      Location:38 → 232
      B41; Band 4.1 homologues
      pfam05902
      Location:4435 → 4539
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:332 → 368
      FA; FERM adjacent (FA)
      cl17171
      Location:227 → 321
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein
    Heading Accession and Version

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