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    lin-26 Transcription factor lin-26 [ Caenorhabditis elegans ]

    Gene ID: 3565051, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lin-26
    Official Full Name
    Transcription factor lin-26
    Primary source
    WormBase:WBGene00003012
    Locus tag
    CELE_F18A1.2
    See related
    AllianceGenome:WB:WBGene00003012
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including establishment or maintenance of epithelial cell apical/basal polarity; positive regulation of transcription by RNA polymerase II; and vulval development. Located in nucleus. Is expressed in several structures, including epithelial cell; germ line; gonad; hypodermis; and somatic gonad precursor. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lin-26 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    5
    Sequence:
    Chromosome: II; NC_003280.10 (7682198..7684764)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene BED-type domain-containing protein;LIn-26 Related Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Receptor L-domain domain-containing protein Neighboring gene Protein pid-1 Neighboring gene Na(+)/H(+) exchanger protein 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Caenorhabditis elegans gene lin-26 is required to specify the fates of hypodermal cells and encodes a presumptive zinc-finger transcription factor. Labouesse M, et al. Development, 1994 Sep. PMID 7956818
    2. The Caenorhabditis elegans LIN-26 protein is required to specify and/or maintain all non-neuronal ectodermal cell fates. Labouesse M, et al. Development, 1996 Sep. PMID 8787733
    3. Deficiency screen based on the monoclonal antibody MH27 to identify genetic loci required for morphogenesis of the Caenorhabditis elegans embryo. Labouesse M. Dev Dyn, 1997 Sep. PMID 9286592
    4. A tissue-specific knock-out strategy reveals that lin-26 is required for the formation of the somatic gonad epithelium in Caenorhabditis elegans. den Boer BG, et al. Development, 1998 Aug. PMID 9671593
    5. A screen for genetic loci required for hypodermal cell and glial-like cell development during Caenorhabditis elegans embryogenesis. Chanal P, et al. Genetics, 1997 May. PMID 9136011, Free PMC Article

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that the hypodermal fate regulator LIN-26, and the GATA factor ELT-6 positively regulate lin-39 expression in the embryonic precursors to the Vulval Precursor Cells (VPCs).
      Title: Multiple transcription factors directly regulate Hox gene lin-39 expression in ventral hypodermal cells of the C. elegans embryo and larva, including the hypodermal fate regulators LIN-26 and ELT-6.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ectoderm development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epidermis development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment or maintenance of epithelial cell apical/basal polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gonad development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in reproductive process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vulval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Transcription factor lin-26
    NP_001022092.1
    • Confirmed by transcript evidence
    NP_001293586.1
    • Confirmed by transcript evidence
    NP_001293587.1
    • Confirmed by transcript evidence
    NP_001343760.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      7682198..7684764
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001356872.3 → NP_001343760.1  Transcription factor lin-26 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A2C9C321, Q27355, Q9U5Z4, U4PC59, U4PFD0
      Conserved Domains (1) summary
      sd00017
      Location:355 → 381
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001306658.3 → NP_001293587.1  Transcription factor lin-26 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293587.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q27355
      UniProtKB/TrEMBL
      U4PC59
      Conserved Domains (1) summary
      sd00017
      Location:337 → 363
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_001306657.3 → NP_001293586.1  Transcription factor lin-26 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293586.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PFD0

    4. NM_001026921.6 → NP_001022092.1  Transcription factor lin-26 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022092.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q27355
      Conserved Domains (1) summary
      sd00017
      Location:303 → 329
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q27355.3

    Gene LinkOut

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