rpy-1 43 kDa receptor-associated protein of the synapse homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: rpy-1
Official Full Name: 43 kDa receptor-associated protein of the synapse homolog
Primary source: WormBase:WBGene00004507
Locus tag: CELE_C18H9.7
See related: AllianceGenome:WB:WBGene00004507
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable acetylcholine receptor binding activity. Predicted to be involved in cholinergic synaptic transmission and positive regulation of neuromuscular synaptic transmission. Predicted to be located in synapse. Predicted to be active in neuromuscular junction and plasma membrane. Is expressed in body wall musculature; enteric muscle; nervous system; and reproductive system. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 11 and fetal akinesia deformation sequence syndrome 2. Orthologous to human RAPSN (receptor associated protein of the synapse). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See rpy-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 13

Sequence:: Chromosome: II; NC_003280.10 (6702233..6705643, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

cullin (CUL)-3 as a component of E3 ligase and KEL-8 as the substrate adaptor of RPY-1.
Title: Control of rapsyn stability by the CUL-3-containing E3 ligase complex.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C18H9.7 (e-PCR)
- UniSTS:308616

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables acetylcholine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables acetylcholine receptor binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-membrane adaptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuromuscular synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic transmission, cholinergic	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in neuromuscular junction	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 43 kDa receptor-associated protein of the synapse homolog

NP_001379705.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

6702233..6705643 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001393105.1 → NP_001379705.1 43 kDa receptor-associated protein of the synapse homolog [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q09485

Conserved Domains (5) summary

COG0457
Location:35 → 183

TPR; Tetratricopeptide (TPR) repeat [General function prediction only]

sd00006
Location:102 → 130

TPR; TPR repeat [structural motif]

pfam13424
Location:222 → 301

TPR_12; Tetratricopeptide repeat

cd16478
Location:390 → 438

RING-H2_Rapsyn; RING finger, H2 subclass, found in 43 kDa receptor-associated protein of the synapse (Rapsyn) and similar proteins

cl24038
Location:20 → 97

SNAP; Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family