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    H27A22.1 glutaminyl-peptide cyclotransferase [ Caenorhabditis elegans ]

    Gene ID: 179482, updated on 9-Dec-2024

    Summary

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    Official Symbol
    H27A22.1
    Official Full Name
    glutaminyl-peptide cyclotransferase
    Primary source
    WormBase:WBGene00010418
    Locus tag
    CELE_H27A22.1
    See related
    AllianceGenome:WB:WBGene00010418
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable glutaminyl-peptide cyclotransferase activity and zinc ion binding activity. Is expressed in head; hypodermis; pharynx; and tail. Orthologous to several human genes including QPCT (glutaminyl-peptide cyclotransferase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See H27A22.1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    6
    Sequence:
    Chromosome: V; NC_003283.11 (10602555..10605581)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Mitochondrial import inner membrane translocase subunit TIM50 Neighboring gene ncRNA Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Caenorhabditis elegans RDE-10/RDE-11 complex regulates RNAi by promoting secondary siRNA amplification. Zhang C, et al. Curr Biol, 2012 May 22. PMID 22542102, Free PMC Article
    2. CCAR-1 works together with the U2AF large subunit UAF-1 to regulate alternative splicing. Lugano DI, et al. RNA Biol, 2024 Jan. PMID 38126797, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutaminyl-peptide cyclotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutaminyl-peptide cyclotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glutaminyl-peptide cyclotransferase
    NP_001041143.1
    • Confirmed by transcript evidence
    NP_001041144.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      10602555..10605581
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001047679.5 → NP_001041144.1  glutaminyl-peptide cyclotransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001041144.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EBT9
      Conserved Domains (1) summary
      cd03880
      Location:50 → 350
      M28_QC_like; M28 Zn-peptidase glutaminyl cyclase

    2. NM_001047678.6 → NP_001041143.1  glutaminyl-peptide cyclotransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001041143.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EF46
      Conserved Domains (1) summary
      cd03880
      Location:36 → 336
      M28_QC_like; M28 Zn-peptidase glutaminyl cyclase
    Nucleotide Protein
    Heading Accession and Version

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