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    trx-1 Thioredoxin-1 [ Caenorhabditis elegans ]

    Gene ID: 181863, updated on 9-Dec-2024

    Summary

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    Official Symbol
    trx-1
    Official Full Name
    Thioredoxin-1
    Primary source
    WormBase:WBGene00015062
    Locus tag
    CELE_B0228.5
    See related
    AllianceGenome:WB:WBGene00015062
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables protein-disulfide reductase activity. Involved in determination of adult lifespan. Located in several cellular components, including dendrite; neuronal cell body; and non-motile cilium. Is expressed in head neurons; intestine; and in male. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See trx-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003280.10 (7752637..7753600, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Copine family protein 2 Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Thioredoxin is related to life span regulation and oxidative stress response in Caenorhabditis elegans. Jee C, et al. Genes Cells, 2005 Dec. PMID 16324156
    2. Lifespan decrease in a Caenorhabditis elegans mutant lacking TRX-1, a thioredoxin expressed in ASJ sensory neurons. Miranda-Vizuete A, et al. FEBS Lett, 2006 Jan 23. PMID 16387300
    3. Thioredoxin shapes the C. elegans sensory response to Pseudomonas produced nitric oxide. Hao Y, et al. Elife, 2018 Jul 17. PMID 30014846, Free PMC Article
    4. Left-right asymmetry in oxidative stress sensing neurons in C. elegans. Quintin S, et al. MicroPubl Biol, 2022. PMID 36338152, Free PMC Article
    5. DNA nanodevices map enzymatic activity in organelles. Dan K, et al. Nat Nanotechnol, 2019 Mar. PMID 30742135, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression of thioredoxin-1 in the ASJ neuron corresponds with and enhances intrinsic regenerative capacity under lesion conditioning in C. elegans.
      Title: Expression of thioredoxin-1 in the ASJ neuron corresponds with and enhances intrinsic regenerative capacity under lesion conditioning in C. elegans.
    2. Mitochondrial thioredoxin system is required for enhanced stress resistance and extended longevity in long-lived mitochondrial mutants.
      Title: Mitochondrial thioredoxin system is required for enhanced stress resistance and extended longevity in long-lived mitochondrial mutants.
    3. Trx-1 regulates intestinal SKN-1 nuclear localization in a cell non-autonomous manner.
      Title: TRX-1 Regulates SKN-1 Nuclear Localization Cell Non-autonomously in Caenorhabditis elegans.
    4. TRX-1 is a thioredoxin homolog. Worms lacking this gene display reduced life span and sensitivity toward oxidative stress.
      Title: Thioredoxin is related to life span regulation and oxidative stress response in Caenorhabditis elegans.
    5. TRX-1 acts as a fluctuating neuronal signaling modulator within ASJ neurons to monitor the adjustment of neuropeptide expression, including insulin-like proteins, during dauer formation in response to adverse environmental conditions.
      Title: The thioredoxin TRX-1 modulates the function of the insulin-like neuropeptide DAF-28 during dauer formation in Caenorhabditis elegans.
    6. Dietary restriction activates TRX-1 in ASJ neurons during aging, which in turn triggers TRX-1-dependent mechanisms to extend adult lifespan in the worm.
      Title: The thioredoxin TRX-1 regulates adult lifespan extension induced by dietary restriction in Caenorhabditis elegans.
    7. Suppression of the C. elegans thioredoxin orthologs trx-1 and trx-2, involved in the redox chaperone activity of exo-3, overrides the protective effect of cep-1 RNAi treatment on neuronal integrity, neuronal function, mean and maximum life span.
      Title: Apurinic/apyrimidinic endonuclease 1, p53, and thioredoxin are linked in control of aging in C. elegans.
    8. Data describe a Caenorhabditis elegans thioredoxin (TRX-1), encoded by the gene B0228.5, that is expressed in ASJ ciliated sensory neurons.
      Title: Lifespan decrease in a Caenorhabditis elegans mutant lacking TRX-1, a thioredoxin expressed in ASJ sensory neurons.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein-disulfide reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-disulfide reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in non-motile cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Thioredoxin-1
    NP_001021885.1
    • Confirmed by transcript evidence
    NP_001021886.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      7752637..7753600 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001026715.7 → NP_001021886.1  Thioredoxin-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021886.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09433
      Conserved Domains (1) summary
      pfam00085
      Location:7 → 110
      Thioredoxin; Thioredoxin

    2. NM_001026714.4 → NP_001021885.1  Thioredoxin-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021885.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09433, Q306X0, Q7YZF7
      Conserved Domains (1) summary
      pfam00085
      Location:16 → 111
      Thioredoxin; Thioredoxin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09433.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.