crh-1 CREB homolog crh-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: crh-1
Official Full Name: CREB homolog crh-1
Primary source: WormBase:WBGene00000793
Locus tag: CELE_Y41C4A.4
See related: AllianceGenome:WB:WBGene00000793
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables identical protein binding activity and transcription coactivator binding activity. Involved in determination of adult lifespan; intracellular signal transduction; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of transcription regulator complex. Is expressed in several structures, including germ line; gonad; head ganglion; intestine; and neurons. Used to study cardiovascular system disease. Human ortholog(s) of this gene implicated in Parkinson's disease; alcohol dependence; and heroin dependence. Orthologous to human ATF1 (activating transcription factor 1); CREB1 (cAMP responsive element binding protein 1); and CREM (cAMP responsive element modulator). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See crh-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 11

Sequence:: Chromosome: III; NC_003281.10 (11657767..11693981)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of circRNAs from the crh-1 gene extends the mean lifespan in Caenorhabditis elegans.
Title: Loss of circRNAs from the crh-1 gene extends the mean lifespan in Caenorhabditis elegans.
Removal of this single isoform of creb1/crh-1 shows defects in long-term memory formation in the animal and expression of CREB1/CRH-1e in a single pair of neurons is sufficient to rescue the memory defects seen in the mutant animals
Title: Differential Regulation of Innate and Learned Behavior by Creb1/Crh-1 in Caenorhabditis elegans.
Here the authors show that the Caenorhabditis elegans SHN-1/Shank binds L-type calcium channels and that increased and decreased shn-1 gene dosage alter L-channel current and activity-induced expression of a CRH-1/CREB transcriptional target (gem-4 Copine).
Title: Shank is a dose-dependent regulator of Ca(v)1 calcium current and CREB target expression.
Both CRH-1 and FLP-6 are necessary and sufficient for longevity at warm temperatures.
Title: A C. elegans Thermosensory Circuit Regulates Longevity through crh-1/CREB-Dependent flp-6 Neuropeptide Signaling.
In Caenorhabditis elegans, the amine neurotransmitter octopamine activates a CREB homolog, CRH-1, in cholinergic SIA neurons, whereas dopamine suppresses CREB activation by inhibiting octopamine signaling in response to food stimuli.
Title: Dopamine modulates acetylcholine release via octopamine and CREB signaling in Caenorhabditis elegans.
crh-1 is essential for long-term memory for context conditioning and habituation.
Title: Genetic dissection of memory for associative and non-associative learning in Caenorhabditis elegans.
This study demonistrated that crh-1 is required for long-term habituation and show that the interneurons of the tap withdrawal response circuit are the locus of plasticity for long-term mechanosensory habituation in C. elegans
Title: Tap withdrawal circuit interneurons require CREB for long-term habituation in Caenorhabditis elegans.
Downregulation of crtc-1 increases lifespan in a crh-1-dependent manner and directly reducing crh-1 expression increases longevity, substantiating a role for CRTCs and CREB in ageing
Title: Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB.
Crh-1 is required for long-term associative memory, but not for learning or short-term memory. Its expression declines with age and differs in the longevity mutants, and its activity correlate with memory performance.
Title: Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age.
In c. elegans, the CREB ortholog CRH-1 activates a CREB protein fusion reporter in a subset of neurons during starvation.
Title: Starvation induces cAMP response element-binding protein-dependent gene expression through octopamine-Gq signaling in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y41C4A.3 (e-PCR)
- UniSTS:316191

Y41C4A.4 (e-PCR)
- UniSTS:322402

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to stimulus	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: CREB homolog crh-1

NP_001022859.1

Confirmed by transcript evidence

NP_001022860.1

Confirmed by transcript evidence

NP_001022861.1

Confirmed by transcript evidence

NP_001022862.1

Confirmed by transcript evidence

NP_001022863.1

Confirmed by transcript evidence

NP_001255135.1

Partially confirmed by transcript evidence

NP_001255136.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

11657767..11693981

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001027690.4 → NP_001022861.1 CREB homolog crh-1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q8I4D8

Conserved Domains (2) summary

cd14690
Location:255 → 309

bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

pfam02173
Location:17 → 57

pKID; pKID domain
NM_001027692.4 → NP_001022863.1 CREB homolog crh-1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

G5ECG1

Conserved Domains (2) summary

cd14690
Location:247 → 301

bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

pfam02173
Location:9 → 49

pKID; pKID domain
NM_001027688.6 → NP_001022859.1 CREB homolog crh-1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

G5EBL5

Conserved Domains (2) summary

cd14690
Location:266 → 320

bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

pfam02173
Location:28 → 68

pKID; pKID domain
NM_001027691.4 → NP_001022862.1 CREB homolog crh-1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q8I4D7

Conserved Domains (2) summary

cd14690
Location:272 → 326

bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

pfam02173
Location:34 → 74

pKID; pKID domain
NM_001027689.3 → NP_001022860.1 CREB homolog crh-1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

D0Z5N1, D0Z5N2, G5EBL5, G5ECG1, Q8I4D7, Q8I4D8, Q9U2I0

Conserved Domains (2) summary

cd14690
Location:268 → 322

bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

pfam02173
Location:28 → 68

pKID; pKID domain
NM_001268206.3 → NP_001255135.1 CREB homolog crh-1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

D0Z5N1

Conserved Domains (1) summary

cd14690
Location:369 → 423

bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
NM_001268207.3 → NP_001255136.1 CREB homolog crh-1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

D0Z5N2

Conserved Domains (1) summary

cd14690
Location:130 → 184

bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain