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    ZK512.2 ATP-dependent RNA helicase;putative ATP-dependent RNA helicase DDX55 homolog [ Caenorhabditis elegans ]

    Gene ID: 176292, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ZK512.2
    Official Full Name
    ATP-dependent RNA helicase;putative ATP-dependent RNA helicase DDX55 homolog
    Primary source
    WormBase:WBGene00013983
    Locus tag
    CELE_ZK512.2
    See related
    AllianceGenome:WB:WBGene00013983
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and RNA helicase activity. Predicted to be located in P granule. Predicted to be active in nucleolus. Is expressed in several structures, including body wall musculature; intestine; non-striated muscle; pharynx; and tail. Orthologous to human DDX55 (DEAD-box helicase 55). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ZK512.2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    6
    Sequence:
    Chromosome: III; NC_003281.10 (9141749..9144794, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein;putative vesicular glutamate transporter eat-4 Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene Signal recognition particle 9 kDa protein Neighboring gene Uncharacterized protein Neighboring gene RING finger protein nhl-1;RING-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional identification of microRNA-centered complexes in C. elegans. Hebbar S, et al. Sci Rep, 2022 May 3. PMID 35504914, Free PMC Article
    2. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in P granule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ATP-dependent RNA helicase;putative ATP-dependent RNA helicase DDX55 homolog
    NP_001254980.1
    • Confirmed by transcript evidence
    NP_001254981.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      9141749..9144794 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268051.2 → NP_001254980.1  putative ATP-dependent RNA helicase DDX55 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254980.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34640
      Conserved Domains (4) summary
      smart00487
      Location:24 → 220
      DEXDc; DEAD-like helicases superfamily
      cd00079
      Location:232 → 362
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd00268
      Location:17 → 219
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
      pfam13959
      Location:398 → 457
      DUF4217; Domain of unknown function (DUF4217)

    2. NM_001268052.3 → NP_001254981.1  ATP-dependent RNA helicase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254981.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2FLF4
      Conserved Domains (4) summary
      COG0513
      Location:7 → 342
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd00079
      Location:166 → 296
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam13959
      Location:332 → 391
      DUF4217; Domain of unknown function (DUF4217)
      cl21455
      Location:1 → 153
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34640.2

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