T16G12.1 Putative aminopeptidase-2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: T16G12.1
Official Full Name: Putative aminopeptidase-2
Primary source: WormBase:WBGene00011803
Locus tag: CELE_T16G12.1
See related: AllianceGenome:WB:WBGene00011803
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Involved in embryo development; regulation of egg-laying behavior; and regulation of meiotic cell cycle process involved in oocyte maturation. Predicted to be active in cytoplasm; extracellular space; and membrane. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See T16G12.1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 30

Sequence:: Chromosome: III; NC_003281.10 (10040181..10049857, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T16G12.1 (e-PCR)
- UniSTS:308048

T16G12.2 (e-PCR)
- UniSTS:310869

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables aminopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloaminopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in embryo development ending in birth or egg hatching	IGI Inferred from Genetic Interaction more info	PubMed
involved_in oogenesis	IEA Inferred from Electronic Annotation more info
involved_in peptide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of egg-laying behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of egg-laying behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of meiotic cell cycle process involved in oocyte maturation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of meiotic cell cycle process involved in oocyte maturation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Putative aminopeptidase-2

NP_499230.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

10040181..10049857 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066829.4 → NP_499230.2 Putative aminopeptidase-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499230.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q22531

Conserved Domains (3) summary

cd09601
Location:88 → 549

M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)

pfam01433
Location:999 → 1402

Peptidase_M1; Peptidase family M1

pfam11838
Location:1542 → 1839

ERAP1_C; ERAP1-like C-terminal domain