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    ric-4 Synaptosomal-associated protein [ Caenorhabditis elegans ]

    Gene ID: 179427, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ric-4
    Official Full Name
    Synaptosomal-associated protein
    Primary source
    WormBase:WBGene00004364
    Locus tag
    CELE_Y22F5A.3
    See related
    AllianceGenome:WB:WBGene00004364
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable SNAP receptor activity and syntaxin binding activity. Involved in cholinergic synaptic transmission. Located in plasma membrane and synapse. Is expressed in several structures, including excretory gland cell; intestinal cell; nervous system; pharyngeal gland cell; and rectal gland cell. Human ortholog(s) of this gene implicated in Down syndrome and congenital myasthenic syndrome 18. Orthologous to several human genes including SNAP25 (synaptosome associated protein 25). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ric-4 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    6
    Sequence:
    Chromosome: V; NC_003283.11 (10261131..10270314, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Serine/threonine-protein kinase akt-1 Neighboring gene RNA-binding protein RO60 Neighboring gene Nuclear Hormone Receptor family Neighboring gene Serpentine Receptor, class T Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The SNARE complex formed by RIC-4/SEC-22/SYX-2 promotes C. elegans epidermal wound healing. Shao Q, et al. Cell Rep, 2023 Nov 28. PMID 37910502
    2. Neuron cell type-specific SNAP-25 expression driven by multiple regulatory elements in the nematode Caenorhabditis elegans. Hwang SB, et al. J Mol Biol, 2003 Oct 17. PMID 14529613
    3. Interspecies complementation identifies a pathway to assemble SNAREs. Parra-Rivas LA, et al. iScience, 2022 Jul 15. PMID 35754735, Free PMC Article
    4. Presynaptic ryanodine receptors are required for normal quantal size at the Caenorhabditis elegans neuromuscular junction. Liu Q, et al. J Neurosci, 2005 Jul 20. PMID 16033884, Free PMC Article
    5. Tomosyn inhibits synaptic vesicle priming in Caenorhabditis elegans. Gracheva EO, et al. PLoS Biol, 2006 Jul. PMID 16895441, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The plasma membrane-associated SNAREs syntaxin/unc-64 and SNAP-25/ric-4 function in parallel in regulating fat storage in C. elegans and regulate fat storage.
      Title: UNC-64 and RIC-4, the plasma membrane-associated SNAREs syntaxin and SNAP-25, regulate fat storage in nematode Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables syntaxin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic transmission, cholinergic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle fusion to presynaptic active zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle priming IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Synaptosomal-associated protein
    NP_001123033.1
    • Confirmed by transcript evidence
    NP_505641.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      10261131..10270314 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073240.9 → NP_505641.2  Synaptosomal-associated protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505641.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O62414
      Conserved Domains (3) summary
      cd15885
      Location:145 → 203
      SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
      cd15889
      Location:16 → 80
      SNARE_SNAP25N_23N; N-terminal SNARE motif of SNAP25 and SNAP23
      pfam00835
      Location:91 → 143
      SNAP-25; SNAP-25 family

    2. NM_001129561.4 → NP_001123033.1  Synaptosomal-associated protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001123033.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A5PEW5
      Conserved Domains (3) summary
      cd15885
      Location:172 → 230
      SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
      cd15889
      Location:45 → 107
      SNARE_SNAP25N_23N; N-terminal SNARE motif of SNAP25 and SNAP23
      pfam00835
      Location:118 → 170
      SNAP-25; SNAP-25 family
    Nucleotide Protein
    Heading Accession and Version

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