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    acdh-1 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial [ Caenorhabditis elegans ]

    Gene ID: 172358, updated on 9-Dec-2024

    Summary

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    Official Symbol
    acdh-1
    Official Full Name
    Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial
    Primary source
    WormBase:WBGene00016943
    Locus tag
    CELE_C55B7.4
    See related
    AllianceGenome:WB:WBGene00016943
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable acyl-CoA dehydrogenase activity. Involved in defense response to Gram-negative bacterium and innate immune response. Predicted to be active in mitochondrion. Is expressed in E lineage cell; hypodermis; intestine; and neurons. Orthologous to human ACADSB (acyl-CoA dehydrogenase short/branched chain). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See acdh-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (6497436..6499560)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Lariat debranching enzyme Neighboring gene Mediator of RNA polymerase II transcription subunit 18 Neighboring gene Unconventional prefoldin RPB5 interactor Neighboring gene Protein-tyrosine phosphatase Neighboring gene Protein kinase domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. acdh-1 transcripts are expressed in the intestine. Updike D. MicroPubl Biol, 2017 Jul 20. PMID 32550343, Free PMC Article
    2. Diet-induced developmental acceleration independent of TOR and insulin in C. elegans. MacNeil LT, et al. Cell, 2013 Mar 28. PMID 23540701, Free PMC Article
    3. Metabolic network rewiring of propionate flux compensates vitamin B12 deficiency in C. elegans. Watson E, et al. Elife, 2016 Jul 6. PMID 27383050, Free PMC Article
    4. C. elegans as a model for inter-individual variation in metabolism. Fox BW, et al. Nature, 2022 Jul. PMID 35794472, Free PMC Article
    5. Interspecies systems biology uncovers metabolites affecting C. elegans gene expression and life history traits. Watson E, et al. Cell, 2014 Feb 13. PMID 24529378, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables acyl-CoA dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-CH group of donors IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial
    NP_001367696.1
    • Confirmed by transcript evidence
    NP_001370604.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      6497436..6499560
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001383261.2 → NP_001370604.1  Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KZG6
      Conserved Domains (1) summary
      cd01158
      Location:50 → 420
      SCAD_SBCAD; Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases

    2. NM_001380557.1 → NP_001367696.1  Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IAB6
      Conserved Domains (1) summary
      cl09933
      Location:1 → 230
      ACAD; Acyl-CoA dehydrogenase
    Nucleotide Protein
    Heading Accession and Version

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