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    nep-9 Neprilysin [ Caenorhabditis elegans ]

    Gene ID: 173683, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nep-9
    Official Full Name
    Neprilysin
    Primary source
    WormBase:WBGene00017554
    Locus tag
    CELE_F18A12.5
    See related
    AllianceGenome:WB:WBGene00017554
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in protein processing. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human KEL (Kell metallo-endopeptidase (Kell blood group)) and ECEL1 (endothelin converting enzyme like 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nep-9 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    15
    Sequence:
    Chromosome: II; NC_003280.10 (3395791..3399312, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene NEPrilysin metallopeptidase family Neighboring gene NEPrilysin metallopeptidase family Neighboring gene Peptidase M13 C-terminal domain-containing protein;Peptidase_M13 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Increasing Complexity of the N-Glycome During Caenorhabditis Development. Wilson IBH, et al. Mol Cell Proteomics, 2023 Mar. PMID 36717059, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Neprilysin
    NP_494531.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      3395791..3399312 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062130.4 → NP_494531.2  Neprilysin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_494531.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O16789
      Conserved Domains (1) summary
      cd08662
      Location:87 → 698
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
    Nucleotide Protein
    Heading Accession and Version

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