anc-1 Calponin-homology (CH) domain-containing protein;KASH domain-containing protein;Nuclear anchorage protein 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: anc-1
Official Full Name: Calponin-homology (CH) domain-containing protein;KASH domain-containing protein;Nuclear anchorage protein 1
Primary source: WormBase:WBGene00000140
Locus tag: CELE_ZK973.6
See related: AllianceGenome:WB:WBGene00000140
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable actin binding activity and kinesin binding activity. Involved in cytoskeleton organization; nucleus organization; and pronuclear migration. Located in nuclear envelope and perinuclear region of cytoplasm. Is expressed in several structures, including body wall musculature. Used to study Emery-Dreifuss muscular dystrophy. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita (multiple); bipolar disorder; cerebellar ataxia (multiple); and muscular dystrophy (multiple). Orthologous to several human genes including SYNE1 (spectrin repeat containing nuclear envelope protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See anc-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 31

Sequence:: Chromosome: I; NC_003279.8 (4318033..4359092)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Nesprin-1/-2 ortholog ANC-1 regulates organelle positioning in C. elegans independently from its KASH or actin-binding domains.
Title: The Nesprin-1/-2 ortholog ANC-1 regulates organelle positioning in C. elegans independently from its KASH or actin-binding domains.
Our study highlights an emerging, broad role for ANC-1 in neuronal development, and unveils a new and unexpected mechanism by which RPM-1 functions.
Title: The Nesprin family member ANC-1 regulates synapse formation and axon termination by functioning in a pathway with RPM-1 and β-Catenin.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T03A1.4 (e-PCR)
- UniSTS:310621

T03A1.3 (e-PCR)
- UniSTS:318402

STS1-123 (e-PCR)
- UniSTS:241608

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables kinesin binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-folding chaperone binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular localization	IEA Inferred from Electronic Annotation more info
involved_in cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in localization	TAS Traceable Author Statement more info	PubMed
involved_in nuclear migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleus localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleus organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleus organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pronuclear migration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in nuclear envelope	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info
located_in nuclear outer membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Calponin-homology (CH) domain-containing protein;KASH domain-containing protein;Nuclear anchorage protein 1

NP_001343707.1

Confirmed by transcript evidence

NP_001343735.1

Confirmed by transcript evidence

NP_491353.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

4318033..4359092

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001356817.3 → NP_001343707.1 Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2C9C3A7

Conserved Domains (5) summary

TIGR04527
Location:1945 → 2071

mycoplas_twoTM; two transmembrane protein

pfam00307
Location:16 → 124

CH; Calponin homology (CH) domain

pfam10541
Location:8485 → 8537

KASH; Nuclear envelope localization domain

cl25732
Location:5834 → 6670

SMC_N; RecF/RecN/SMC N terminal domain

cl26511
Location:2876 → 3906

Neuromodulin_N; Gap junction protein N-terminal region
NM_058952.5 → NP_491353.2 Nuclear anchorage protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491353.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O61841, O61842, Q6IMP3, Q9N4M4

Conserved Domains (6) summary

COG0419
Location:2272 → 2886

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

COG1196
Location:6744 → 7580

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR04527
Location:1952 → 2078

mycoplas_twoTM; two transmembrane protein

pfam00307
Location:25 → 125

CH; Calponin homology (CH) domain

pfam10541
Location:8492 → 8544

KASH; Nuclear envelope localization domain

cl19511
Location:7746 → 7866

DUF2317; Uncharacterized protein conserved in bacteria (DUF2317)
NM_001356818.3 → NP_001343735.1 KASH domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2C9C2Z1

Conserved Domains (5) summary

PTZ00121
Location:1878 → 2908

PTZ00121; MAEBL; Provisional

COG0419
Location:1269 → 1881

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

COG1196
Location:5739 → 6575

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR04527
Location:947 → 1073

mycoplas_twoTM; two transmembrane protein

pfam10541
Location:7487 → 7539

KASH; Nuclear envelope localization domain