U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    cps-6 Endonuclease G, mitochondrial [ Caenorhabditis elegans ]

    Gene ID: 172045, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    cps-6
    Official Full Name
    Endonuclease G, mitochondrial
    Primary source
    WormBase:WBGene00000787
    Locus tag
    CELE_C41D11.8
    See related
    AllianceGenome:WB:WBGene00000787
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables endonuclease activity; protein homodimerization activity; and sequence-specific DNA binding activity. Involved in RNA catabolic process and apoptotic DNA fragmentation. Located in mitochondrion. Orthologous to human ENDOG (endonuclease G). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See cps-6 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003279.8 (4446586..4448461, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Cysteine/serine-rich nuclear protein N-terminal domain-containing protein Neighboring gene Eukaryotic translation initiation factor 3 subunit H Neighboring gene TM2 domain-containing protein C41D11.9 Neighboring gene Protein cmt-1

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Crystal structure of endonuclease G in complex with DNA reveals how it nonspecifically degrades DNA as a homodimer. Lin JL, et al. Nucleic Acids Res, 2016 Dec 1. PMID 27738134, Free PMC Article
    2. Development: Eliminating paternal mitochondria. Baumann K. Nat Rev Mol Cell Biol, 2016 Jul 21. PMID 27440316
    3. Mitochondrial endonuclease G mediates breakdown of paternal mitochondria upon fertilization. Zhou Q, et al. Science, 2016 Jul 22. PMID 27338704, Free PMC Article
    4. Structural insights into apoptotic DNA degradation by CED-3 protease suppressor-6 (CPS-6) from Caenorhabditis elegans. Lin JL, et al. J Biol Chem, 2012 Mar 2. PMID 22223640, Free PMC Article
    5. Oxidative Stress Impairs Cell Death by Repressing the Nuclease Activity of Mitochondrial Endonuclease G. Lin JLJ, et al. Cell Rep, 2016 Jul 12. PMID 27346342, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CPS-6 thus acts as a reactive oxygen species sensor to regulate the life and death of cells.
      Title: Oxidative Stress Impairs Cell Death by Repressing the Nuclease Activity of Mitochondrial Endonuclease G.
    2. CPS-6 functions as a paternal mitochondrial degradation factor during animal development.
      Title: Mitochondrial endonuclease G mediates breakdown of paternal mitochondria upon fertilization.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables double-stranded DNA endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables single-stranded DNA endodeoxyribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in RNA catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in apoptotic DNA fragmentation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in apoptotic DNA fragmentation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in apoptotic DNA fragmentation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in apoptotic DNA fragmentation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Endonuclease G, mitochondrial
    NP_491371.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      4446586..4448461 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058970.6 → NP_491371.1  Endonuclease G, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491371.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95NM6
      Conserved Domains (2) summary
      smart00477
      Location:83 → 293
      NUC; DNA/RNA non-specific endonuclease
      COG1864
      Location:10 → 308
      NUC1; DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95NM6.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools