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    F47D12.7 Kelch repeat and BTB domain-containing protein F47D12.7 [ Caenorhabditis elegans ]

    Gene ID: 175891, updated on 9-Dec-2024

    Summary

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    Official Symbol
    F47D12.7
    Official Full Name
    Kelch repeat and BTB domain-containing protein F47D12.7
    Primary source
    WormBase:WBGene00018563
    Locus tag
    CELE_F47D12.7
    See related
    AllianceGenome:WB:WBGene00018563
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in spermatogenic failure 11. Orthologous to human KLHL10 (kelch like family member 10). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See F47D12.7 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    13
    Sequence:
    Chromosome: III; NC_003281.10 (6293247..6296022, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene High mobility group protein 1.2 Neighboring gene Gastrulation-defective protein 3 Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene WD_REPEATS_REGION domain-containing protein;putative WD repeat-containing protein F47D12.9 Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein;Muscarinic acetylcholine receptor gar-2 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Kelch repeat and BTB domain-containing protein F47D12.7
    NP_498380.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      6293247..6296022 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065979.4 → NP_498380.1  Kelch repeat and BTB domain-containing protein F47D12.7 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498380.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09563
      Conserved Domains (5) summary
      smart00612
      Location:369 → 415
      Kelch; Kelch domain
      smart00875
      Location:159 → 228
      BACK; BTB And C-terminal Kelch
      PHA03098
      Location:44 → 554
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:306 → 349
      Kelch; KELCH repeat [structural motif]
      cl02518
      Location:41 → 138
      BTB; BTB/POZ domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09563.1

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