coq-6 Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: coq-6
Official Full Name: Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial
Primary source: WormBase:WBGene00000766
Locus tag: CELE_K07B1.2
See related: AllianceGenome:WB:WBGene00000766
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable oxidoreductase activity. Involved in ubiquinone biosynthetic process. Predicted to be located in mitochondrial inner membrane. Predicted to be extrinsic component of mitochondrial inner membrane. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 6. Orthologous to human COQ6 (coenzyme Q6, monooxygenase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See coq-6 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 8

Sequence:: Chromosome: V; NC_003283.11 (9336762..9338858)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K07B1.3 (e-PCR)
- UniSTS:314632

K07B1.2 (e-PCR)
- UniSTS:312397

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 2-octaprenyl-6-methoxyphenol hydroxylase activity	IEA Inferred from Electronic Annotation more info
enables 4-hydroxy-3-all-trans-hexaprenylbenzoate oxygenase activity	IEA Inferred from Electronic Annotation more info
enables FAD binding	IEA Inferred from Electronic Annotation more info
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ubiquinone biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquinone biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in ubiquinone biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extrinsic component of mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial

NP_505415.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

9336762..9338858

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_073014.5 → NP_505415.2 Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_505415.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O01884

Conserved Domains (2) summary

TIGR01988
Location:19 → 448

Ubi-OHases; Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family

TIGR01989
Location:18 → 444

COQ6; ubiquinone biosynthesis monooxygenase COQ6