xpc-1 XPC (Xeroderma Pigmentosum group C) DNA repair gene homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: xpc-1
Official Full Name: XPC (Xeroderma Pigmentosum group C) DNA repair gene homolog
Primary source: WormBase:WBGene00022296
Locus tag: CELE_Y76B12C.2
See related: AllianceGenome:WB:WBGene00022296
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable damaged DNA binding activity and single-stranded DNA binding activity. Involved in response to UV. Predicted to be located in nucleus. Predicted to be part of XPC complex and nucleotide-excision repair factor 2 complex. Predicted to be active in cytoplasm. Is expressed in germline precursor cell; intestine; and nervous system. Used to study xeroderma pigmentosum. Human ortholog(s) of this gene implicated in pancreatic cancer; serous cystadenocarcinoma; xeroderma pigmentosum; and xeroderma pigmentosum group C. Orthologous to human XPC (XPC complex subunit, DNA damage recognition and repair factor). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See xpc-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 10

Sequence:: Chromosome: IV; NC_003282.8 (1993089..2009027)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y76B12C_67.f (e-PCR)
- UniSTS:323360

Y76B12C_66.a (e-PCR)
- UniSTS:324501

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables damaged DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables damaged DNA binding	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in mismatch repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleotide-excision repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleotide-excision repair	IEA Inferred from Electronic Annotation more info
involved_in response to UV	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of XPC complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of nucleotide-excision repair factor 2 complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: XPC (Xeroderma Pigmentosum group C) DNA repair gene homolog

NP_500156.2

Product from WormBase gene class xpc;
Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

1993089..2009027

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_067755.6 → NP_500156.2 XPC (Xeroderma Pigmentosum group C) DNA repair gene homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_500156.2

Status: REVIEWED

UniProtKB/TrEMBL

Q9N4C3

Conserved Domains (4) summary

smart01032
Location:945 → 1019

BHD_3; Rad4 beta-hairpin domain 3

smart01030
Location:827 → 880

BHD_1; Rad4 beta-hairpin domain 1

smart01031
Location:883 → 936

BHD_2; Rad4 beta-hairpin domain 2

pfam03835
Location:688 → 823

Rad4; Rad4 transglutaminase-like domain