klf-3 Kruppel-like factor 3 [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: klf-3
Official Full Name: Kruppel-like factor 3
Primary source: WormBase:WBGene00003480
Locus tag: CELE_F54H5.4
See related: AllianceGenome:WB:WBGene00003480
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in regulation of gene expression and regulation of lipid metabolic process. Predicted to be located in nucleus. Is expressed in germ line; hypodermis; intestine; and vulva. Orthologous to human KLF12 (KLF transcription factor 12); KLF2 (KLF transcription factor 2); and KLF8 (KLF transcription factor 8). [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See klf-3 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 6

Sequence:: Chromosome: II; NC_003280.10 (6618218..6622171)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data demonstrate that klf-3 is a hitherto unrecognized key regulator of fat metabolism in C. elegans, and is critical for maintaining normal fatty acid composition by regulating genes involved in a fatty acid desaturation pathway.
Title: Mutation in Caenorhabditis elegans Krüppel-like factor, KLF-3 results in fat accumulation and alters fatty acid composition.
overexpression extends health and lifespan
Title: A conserved KLF-autophagy pathway modulates nematode lifespan and mammalian age-associated vascular dysfunction.
klf-3 regulates lipid metabolism, along with acs-1, acs-2, F08A8.1, and F08A8.2, by promoting FA beta-oxidation and, in parallel, may contribute to normal reproductive behavior and fecundity in C. elegans.
Title: Regulation of fat storage and reproduction by Krüppel-like transcription factor KLF3 and fat-associated genes in Caenorhabditis elegans.
Genetic interactions between klf-3 and dsc-4, as well as vit-5 genes, suggest that klf-3 may have an important role in regulating lipid assembly and secretion.
Title: Regulation of lipoprotein assembly, secretion and fatty acid β-oxidation by Krüppel-like transcription factor, klf-3.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

F54H5.4 (e-PCR)
- UniSTS:320085

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of fatty acid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	HEP more info	PubMed
involved_in regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: Kruppel-like factor 3

NP_001022204.1

Partially confirmed by transcript evidence

NP_001022205.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

6618218..6622171

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001027034.6 → NP_001022205.1 Kruppel-like factor 3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022205.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P91329, Q65ZG6

Conserved Domains (3) summary

COG5189
Location:215 → 314

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

sd00017
Location:235 → 254

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:276 → 301

zf-H2C2_2; Zinc-finger double domain
NM_001027033.2 → NP_001022204.1 Kruppel-like factor 3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022204.1

Status: REVIEWED

UniProtKB/TrEMBL

P91329

Conserved Domains (2) summary

sd00017
Location:229 → 248

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:270 → 295

zf-H2C2_2; Zinc-finger double domain