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    lep-2 E3 ubiquitin-protein ligase makorin [ Caenorhabditis elegans ]

    Gene ID: 176918, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lep-2
    Official Full Name
    E3 ubiquitin-protein ligase makorin
    Primary source
    WormBase:WBGene00002278
    Locus tag
    CELE_Y55F3AM.6
    See related
    AllianceGenome:WB:WBGene00002278
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Predicted to be located in cytoplasm. Is expressed in developing hermaphrodite gonad; hypodermis; intestine; neurons; and pharynx. Human ortholog(s) of this gene implicated in central precocious puberty 2. Orthologous to several human genes including MKRN1 (makorin ring finger protein 1); MKRN2 (makorin ring finger protein 2); and MKRN3 (makorin ring finger protein 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lep-2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    7
    Sequence:
    Chromosome: IV; NC_003282.8 (992283..997644)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Sema domain-containing protein Neighboring gene ncRNA Neighboring gene C2H2-type domain-containing protein Neighboring gene SPIN90/Ldb17 leucine-rich domain-containing protein Neighboring gene Mitochondrial inner membrane protease subunit 2;Peptidase S26 domain-containing protein Neighboring gene Ubiquitin carboxyl-terminal hydrolase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Makorin lep-2 and the lncRNA lep-5 regulate lin-28 to schedule sexual maturation of the C. elegans nervous system. Lawson H, et al. Elife, 2019 Jul 2. PMID 31264582, Free PMC Article
    2. The Long Non-Coding RNA lep-5 Promotes the Juvenile-to-Adult Transition by Destabilizing LIN-28. Kiontke KC, et al. Dev Cell, 2019 May 20. PMID 30956008, Free PMC Article
    3. Makorin ortholog LEP-2 regulates LIN-28 stability to promote the juvenile-to-adult transition in Caenorhabditis elegans. Herrera RA, et al. Development, 2016 Mar 1. PMID 26811380, Free PMC Article
    4. A sex-specific switch in a single glial cell patterns the apical extracellular matrix. Fung W, et al. Curr Biol, 2023 Oct 9. PMID 37708887, Free PMC Article
    5. Incenp and an aurora-like kinase form a complex essential for chromosome segregation and efficient completion of cytokinesis. Kaitna S, et al. Curr Biol, 2000 Oct 5. PMID 11050385

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LEP-2 regulates LIN-28 stability to promote the juvenile-to-adult transition in Caenorhabditis elegans
      Title: Makorin ortholog LEP-2 regulates LIN-28 stability to promote the juvenile-to-adult transition in Caenorhabditis elegans.
    2. These studies reveal roles for a Makorin and a lncRNA in timing of sexual differentiation; moreover, they demonstrate deep conservation of the lin-28-let-7 system in controlling the functional maturation of the nervous system.
      Title: The Makorin lep-2 and the lncRNA lep-5 regulate lin-28 to schedule sexual maturation of the C. elegans nervous system.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein polyubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sex differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase makorin
    NP_001023510.1
    • Confirmed by transcript evidence
    NP_001023511.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      992283..997644
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001028340.6 → NP_001023511.1  E3 ubiquitin-protein ligase makorin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023511.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L0R6
      Conserved Domains (2) summary
      PHA03096
      Location:157 → 302
      PHA03096; p28-like protein; Provisional
      cd00162
      Location:212 → 269
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    2. NM_001028339.6 → NP_001023510.1  E3 ubiquitin-protein ligase makorin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023510.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H2L0R6, Q9N373
      Conserved Domains (4) summary
      PHA03096
      Location:157 → 302
      PHA03096; p28-like protein; Provisional
      COG5252
      Location:275 → 331
      COG5252; Uncharacterized conserved protein, contains CCCH-type Zn-finger protein [General function prediction only]
      cd16521
      Location:213 → 267
      RING-HC_MKRN; RING finger, HC subclass, found in the makorin (MKRN) protein family
      pfam15663
      Location:1 → 56
      zf-CCCH_3; Zinc-finger containing family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9N373.1

    Gene LinkOut

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