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    imp-3 IntraMembrane Protease (IMPAS) family [ Caenorhabditis elegans ]

    Gene ID: 177565, updated on 9-Dec-2024

    Summary

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    Official Symbol
    imp-3
    Official Full Name
    IntraMembrane Protease (IMPAS) family
    Primary source
    WormBase:WBGene00016378
    Locus tag
    CELE_C33H5.11
    See related
    AllianceGenome:WB:WBGene00016378
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable aspartic endopeptidase activity, intramembrane cleaving. Predicted to be involved in membrane protein proteolysis and signal peptide processing. Predicted to be located in membrane. Predicted to be active in cytoplasmic side of endoplasmic reticulum membrane and lumenal side of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See imp-3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    10
    Sequence:
    Chromosome: IV; NC_003282.8 (7785999..7789613, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Transmembrane protein 65 Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene putative splicing factor, arginine/serine-rich 6 Neighboring gene CYSTM domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables aspartic endopeptidase activity, intramembrane cleaving IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aspartic endopeptidase activity, intramembrane cleaving IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in membrane protein proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal peptide processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasmic side of endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lumenal side of endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    IntraMembrane Protease (IMPAS) family
    NP_001294163.1
    • Confirmed by transcript evidence
    NP_001294164.1
    • Confirmed by transcript evidence
    NP_001360383.1
    • Confirmed by transcript evidence
    NP_501286.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      7785999..7789613 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068885.8 → NP_501286.2  IntraMembrane Protease (IMPAS) family [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501286.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18408
      Conserved Domains (1) summary
      cl01342
      Location:331 → 512
      Peptidase_A22B; Signal peptide peptidase

    2. NM_001372874.1 → NP_001360383.1  IntraMembrane Protease (IMPAS) family [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AUD2
      Conserved Domains (1) summary
      cl01342
      Location:345 → 526
      Peptidase_A22B; Signal peptide peptidase

    3. NM_001307234.3 → NP_001294163.1  IntraMembrane Protease (IMPAS) family [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294163.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      W6SBE0
      Conserved Domains (1) summary
      cl01342
      Location:187 → 368
      Peptidase_A22B; Signal peptide peptidase

    4. NM_001307235.3 → NP_001294164.1  IntraMembrane Protease (IMPAS) family [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294164.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      W6RQZ7
    Nucleotide Protein
    Heading Accession and Version

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