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    spp-8 Saposin B-type domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177652, updated on 9-Dec-2024

    Summary

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    Official Symbol
    spp-8
    Official Full Name
    Saposin B-type domain-containing protein
    Primary source
    WormBase:WBGene00004993
    Locus tag
    CELE_C28C12.5
    See related
    AllianceGenome:WB:WBGene00004993
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Is expressed in intestine. Human ortholog(s) of this gene implicated in atypical Gaucher's disease due to saposin c deficiency; combined saposin deficiency; and late onset Parkinson's disease. Orthologous to human PSAP (prosaposin). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See spp-8 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    9
    Sequence:
    Chromosome: IV; NC_003282.8 (8481664..8483621)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Transmembrane protein Neighboring gene Saposin B-type domain-containing protein Neighboring gene Helix-loop-helix protein hlh-12 Neighboring gene SXP/RAL-2 family protein Ani s 5-like cation-binding domain-containing protein Neighboring gene SXP /RAL-2-Like protein Family

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NFYB-1 regulates mitochondrial function and longevity via lysosomal prosaposin. Tharyan RG, et al. Nat Metab, 2020 May. PMID 32694663
    2. Degradation of hexosylceramides is required for timely corpse clearance via formation of cargo-containing phagolysosomal vesicles. Holzapfel R, et al. Eur J Cell Biol, 2024 Jun. PMID 38582051
    3. Responses to infection and possible recognition strategies in the innate immune system of Caenorhabditis elegans. Nicholas HR, et al. Mol Immunol, 2004 Jul. PMID 15183927
    4. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article
    5. Transcriptomics of ivermectin response in Caenorhabditis elegans: Integrating abamectin quantitative trait loci and comparison to the Ivermectin-exposed DA1316 strain. Dube F, et al. PLoS One, 2023. PMID 37141255, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Saposin B-type domain-containing protein
    NP_501447.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      8481664..8483621
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069046.7 → NP_501447.1  Saposin B-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501447.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18279
      Conserved Domains (1) summary
      smart00741
      Location:238 → 312
      SapB; Saposin (B) Domains
    Nucleotide Protein
    Heading Accession and Version

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