rme-1 Dynamin-type G domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: rme-1
Official Full Name: Dynamin-type G domain-containing protein
Primary source: WormBase:WBGene00004373
Locus tag: CELE_W06H8.1
See related: AllianceGenome:WB:WBGene00004373
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables ATP hydrolysis activity and protein domain specific binding activity. Involved in several processes, including endocytic recycling; lipid tube assembly involved in organelle fission; and necroptotic process. Located in recycling endosome membrane. Is expressed in coelomocyte; germ line; gonad; intestine; and pharynx. Orthologous to several human genes including EHD1 (EH domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See rme-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 12

Sequence:: Chromosome: V; NC_003283.11 (6208885..6217664)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

show that endogenous C. elegans AMPH-1 colocalizes with RME-1 on recycling endosomes in vivo, that amph-1-deletion mutants are defective in recycling endosome morphology and function.
Title: AMPH-1/Amphiphysin/Bin1 functions with RME-1/Ehd1 in endocytic recycling.
ATP binding is required for oligomerization of mRme-1/EHD1, which in turn is required for its association with endosomes
Title: ATP binding regulates oligomerization and endosome association of RME-1 family proteins.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

W06H8.e (e-PCR)
- UniSTS:322642

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in endocytic recycling	IBA Inferred from Biological aspect of Ancestor more info
involved_in endocytic recycling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid tube assembly involved in organelle fission	IDA Inferred from Direct Assay more info	PubMed
involved_in necroptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of establishment of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in endomembrane system	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in recycling endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in recycling endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in recycling endosome membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Dynamin-type G domain-containing protein

NP_001024194.1

Confirmed by transcript evidence

NP_001024195.1

Confirmed by transcript evidence

NP_001024196.1

Confirmed by transcript evidence

NP_001343865.1

Confirmed by transcript evidence

NP_001343866.1

Confirmed by transcript evidence

NP_001343867.1

Confirmed by transcript evidence

NP_001367910.1

Confirmed by transcript evidence

NP_001379996.1

Confirmed by transcript evidence

NP_001379997.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

6208885..6217664

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001029023.4 → NP_001024194.1 Dynamin-type G domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024194.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EEU7

Conserved Domains (4) summary

smart00027
Location:481 → 574

EH; Eps15 homology domain

cd09913
Location:94 → 334

EHD; Eps15 homology domain (EHD), C-terminal domain

cd00052
Location:492 → 556

EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...

pfam16880
Location:58 → 90

EHD_N; N-terminal EH-domain containing protein
NM_001029025.7 → NP_001024196.1 Dynamin-type G domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024196.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8WSP1

Conserved Domains (4) summary

smart00027
Location:505 → 598

EH; Eps15 homology domain

cd09913
Location:118 → 358

EHD; Eps15 homology domain (EHD), C-terminal domain

cd00052
Location:516 → 580

EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...

pfam16880
Location:82 → 114

EHD_N; N-terminal EH-domain containing protein
NM_001392527.1 → NP_001379996.1 Dynamin-type G domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q7KFZ3, Q9N5B7

Conserved Domains (4) summary

smart00027
Location:678 → 771

EH; Eps15 homology domain

cd09913
Location:291 → 531

EHD; Eps15 homology domain (EHD), C-terminal domain

pfam16880
Location:255 → 287

EHD_N; N-terminal EH-domain containing protein

pfam18150
Location:519 → 625

DUF5600; Domain of unknown function (DUF5600)
NM_001380664.2 → NP_001367910.1 Dynamin-type G domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

G5ECC3, Q7KFZ3

Conserved Domains (4) summary

smart00027
Location:683 → 776

EH; Eps15 homology domain

cd09913
Location:291 → 531

EHD; Eps15 homology domain (EHD), C-terminal domain

pfam16880
Location:255 → 287

EHD_N; N-terminal EH-domain containing protein

pfam18150
Location:519 → 625

DUF5600; Domain of unknown function (DUF5600)
NM_001356657.3 → NP_001343865.1 Dynamin-type G domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2C9C3Z4

Conserved Domains (3) summary

smart00027
Location:505 → 598

EH; Eps15 homology domain

cd09913
Location:113 → 353

EHD; Eps15 homology domain (EHD), C-terminal domain

pfam16880
Location:78 → 109

EHD_N; N-terminal EH-domain containing protein
NM_001356658.3 → NP_001343866.1 Dynamin-type G domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2C9C3S7

Conserved Domains (3) summary

smart00027
Location:500 → 593

EH; Eps15 homology domain

cd09913
Location:113 → 353

EHD; Eps15 homology domain (EHD), C-terminal domain

pfam16880
Location:78 → 109

EHD_N; N-terminal EH-domain containing protein
NM_001029024.5 → NP_001024195.1 Dynamin-type G domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024195.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EFP1

Conserved Domains (4) summary

smart00027
Location:468 → 561

EH; Eps15 homology domain

cd09913
Location:76 → 316

EHD; Eps15 homology domain (EHD), C-terminal domain

cd00052
Location:479 → 543

EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...

pfam16880
Location:40 → 72

EHD_N; N-terminal EH-domain containing protein
NM_001356659.4 → NP_001343867.1 Dynamin-type G domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2C9C352

Conserved Domains (3) summary

smart00027
Location:452 → 545

EH; Eps15 homology domain

cd09913
Location:60 → 300

EHD; Eps15 homology domain (EHD), C-terminal domain

pfam16880
Location:25 → 56

EHD_N; N-terminal EH-domain containing protein
NM_001392528.1 → NP_001379997.1 Dynamin-type G domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q86S80

Conserved Domains (4) summary

smart00027
Location:447 → 540

EH; Eps15 homology domain

cd09913
Location:60 → 300

EHD; Eps15 homology domain (EHD), C-terminal domain

pfam16880
Location:24 → 56

EHD_N; N-terminal EH-domain containing protein

pfam18150
Location:288 → 394

DUF5600; Domain of unknown function (DUF5600)