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    kcc-2 K+/Cl-Cotransporter [ Caenorhabditis elegans ]

    Gene ID: 177370, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kcc-2
    Official Full Name
    K+/Cl-Cotransporter
    Primary source
    WormBase:WBGene00019205
    Locus tag
    CELE_H16O14.1
    See related
    AllianceGenome:WB:WBGene00019205
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables potassium:chloride symporter activity. Involved in chloride transport; potassium ion transport; and regulation of GABAergic synaptic transmission. Predicted to be located in membrane and synapse. Predicted to be active in plasma membrane. Is expressed in body wall musculature; egg-laying apparatus; hermaphrodite distal tip cell; intestine; and neurons. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease; agenesis of the corpus callosum with peripheral neuropathy; developmental and epileptic encephalopathy 34; and idiopathic generalized epilepsy 14. Orthologous to several human genes including SLC12A4 (solute carrier family 12 member 4); SLC12A5 (solute carrier family 12 member 5); and SLC12A7 (solute carrier family 12 member 7). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See kcc-2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    16
    Sequence:
    Chromosome: IV; NC_003282.8 (6040976..6074507)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Pep_M12B_propep domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning, characterization, and gene organization of K-Cl cotransporter from pig and human kidney and C. elegans. Holtzman EJ, et al. Am J Physiol, 1998 Oct. PMID 9755127
    2. An evolutionarily conserved switch in response to GABA affects development and behavior of the locomotor circuit of Caenorhabditis elegans. Han B, et al. Genetics, 2015 Apr. PMID 25644702, Free PMC Article
    3. Two types of chloride transporters are required for GABA(A) receptor-mediated inhibition in C. elegans. Bellemer A, et al. EMBO J, 2011 May 4. PMID 21427702, Free PMC Article
    4. The potassium chloride cotransporter KCC-2 coordinates development of inhibitory neurotransmission and synapse structure in Caenorhabditis elegans. Tanis JE, et al. J Neurosci, 2009 Aug 12. PMID 19675228, Free PMC Article
    5. Transcriptomics of ivermectin response in Caenorhabditis elegans: Integrating abamectin quantitative trait loci and comparison to the Ivermectin-exposed DA1316 strain. Dube F, et al. PLoS One, 2023. PMID 37141255, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. While animals lacking ABTS-1 or the K(+)-Cl(-) cotransporter KCC-2 display only mild behavioural defects, animals lacking both Cl(-) extruders are paralyzed.
      Title: Two types of chloride transporters are required for GABA(A) receptor-mediated inhibition in C. elegans.
    2. KCC-2 coordinates the development of inhibitory neurotransmission with synapse maturation to produce mature neural circuits with appropriate activity levels
      Title: The potassium chloride cotransporter KCC-2 coordinates development of inhibitory neurotransmission and synapse structure in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables chloride:monoatomic cation symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium:chloride symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium:chloride symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell volume homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of synaptic transmission, GABAergic IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    K+/Cl-Cotransporter
    NP_001255278.1
    • Confirmed by transcript evidence
    NP_001255279.2
    • Confirmed by transcript evidence
    NP_001255280.1
    • Confirmed by transcript evidence
    NP_001255281.1
    • Confirmed by transcript evidence
    NP_001368424.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      6040976..6074507
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268352.3 → NP_001255281.1  K+/Cl-Cotransporter [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255281.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0KDV0, D0G908
      Conserved Domains (1) summary
      cl45918
      Location:76 → 1061
      AA_permease_2; Amino acid permease

    2. NM_001268349.3 → NP_001255278.1  K+/Cl-Cotransporter [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255278.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EEC9
      Conserved Domains (1) summary
      cl45918
      Location:94 → 1079
      AA_permease_2; Amino acid permease

    3. NM_001268350.4 → NP_001255279.2  K+/Cl-Cotransporter [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255279.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KZC3
      Conserved Domains (1) summary
      cl45918
      Location:144 → 1129
      AA_permease_2; Amino acid permease

    4. NM_001268351.3 → NP_001255280.1  K+/Cl-Cotransporter [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255280.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KZC2
      Conserved Domains (2) summary
      TIGR00930
      Location:117 → 1102
      2a30; K-Cl cotransporter
      pfam03522
      Location:714 → 1102
      SLC12; Solute carrier family 12

    5. NM_001380258.1 → NP_001368424.1  K+/Cl-Cotransporter [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CJH3
      Conserved Domains (1) summary
      cl45918
      Location:20 → 1005
      AA_permease_2; Amino acid permease
    Nucleotide Protein
    Heading Accession and Version

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