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    eat-17 Rab GTPase-activating protein eat-17 [ Caenorhabditis elegans ]

    Gene ID: 3565805, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eat-17
    Official Full Name
    Rab GTPase-activating protein eat-17
    Primary source
    WormBase:WBGene00020770
    Locus tag
    CELE_T24D11.1
    See related
    AllianceGenome:WB:WBGene00020770
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTPase activator activity. Involved in positive regulation of feeding behavior and regulation of presynaptic dense core granule exocytosis. Located in cholinergic synapse. Is expressed in several structures, including hypodermis; nervous system; pharyngeal-intestinal valve; pharynx; and vulva. Orthologous to human EVI5 (ecotropic viral integration site 5) and EVI5L (ecotropic viral integration site 5 like). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See eat-17 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    13
    Sequence:
    Chromosome: X; NC_003284.9 (16399210..16416840, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Small integral membrane protein 7-like Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The jaw of the worm: GTPase-activating protein EAT-17 regulates grinder formation in Caenorhabditis elegans. Straud S, et al. Genetics, 2013 Sep. PMID 23792950, Free PMC Article
    2. EAT-20, a novel transmembrane protein with EGF motifs, is required for efficient feeding in Caenorhabditis elegans. Shibata Y, et al. Genetics, 2000 Feb. PMID 10655217, Free PMC Article
    3. Effects of genetic mutations and chemical exposures on Caenorhabditis elegans feeding: evaluation of a novel, high-throughput screening assay. Boyd WA, et al. PLoS One, 2007 Dec 5. PMID 18060055, Free PMC Article
    4. RAB-5 and RAB-10 cooperate to regulate neuropeptide release in Caenorhabditis elegans. Sasidharan N, et al. Proc Natl Acad Sci U S A, 2012 Nov 13. PMID 23100538, Free PMC Article
    5. Microbial Colonization Activates an Immune Fight-and-Flight Response via Neuroendocrine Signaling. Singh J, et al. Dev Cell, 2019 Apr 8. PMID 30827896, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. tbc-4 physically interacts with RAB6.2 and is required for grinder formation.
      Title: The jaw of the worm: GTPase-activating protein EAT-17 regulates grinder formation in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of feeding behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of presynaptic dense core granule exocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of presynaptic dense core granule exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cholinergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cholinergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rab GTPase-activating protein eat-17
    NP_001294781.1
    • Confirmed by transcript evidence
    NP_001294782.1
    • Confirmed by transcript evidence
    NP_001294783.1
    • Confirmed by transcript evidence
    NP_001294784.1
    • Confirmed by transcript evidence
    NP_001294848.1
    • Confirmed by transcript evidence
    NP_510666.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      16399210..16416840 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001307853.5 → NP_001294782.1  Rab GTPase-activating protein eat-17 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294782.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      S6FMY8
      Conserved Domains (2) summary
      smart00164
      Location:167 → 374
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      COG1196
      Location:471 → 775
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. NM_001307855.6 → NP_001294784.1  Rab GTPase-activating protein eat-17 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294784.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q19101, S6EZL6, S6F527, S6FMY8, S6FWN8, U4PBB2
      Conserved Domains (2) summary
      smart00164
      Location:170 → 377
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      COG1196
      Location:474 → 778
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    3. NM_001307852.3 → NP_001294781.1  Rab GTPase-activating protein eat-17 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294781.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      S6EZL6
      Conserved Domains (2) summary
      smart00164
      Location:107 → 314
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      COG1196
      Location:411 → 715
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    4. NM_001307854.3 → NP_001294783.1  Rab GTPase-activating protein eat-17 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294783.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      S6FWN8
      Conserved Domains (2) summary
      smart00164
      Location:67 → 274
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      COG1196
      Location:371 → 675
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    5. NM_078265.4 → NP_510666.1  Rab GTPase-activating protein eat-17 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510666.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19101
      Conserved Domains (1) summary
      COG1196
      Location:52 → 356
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    6. NM_001307919.3 → NP_001294848.1  Rab GTPase-activating protein eat-17 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294848.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PBB2
      Conserved Domains (1) summary
      COG1196
      Location:7 → 286
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    Nucleotide Protein
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