ift-74 Intraflagellar transport protein 74 homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ift-74
Official Full Name: Intraflagellar transport protein 74 homolog
Primary source: WormBase:WBGene00016005
Locus tag: CELE_C18H9.8
See related: AllianceGenome:WB:WBGene00016005
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables microtubule binding activity. Involved in chemotaxis; detection of stimulus involved in sensory perception; and intraciliary transport. Located in non-motile cilium. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 22; Joubert syndrome; and spermatogenic failure 58. Orthologous to human IFT74 (intraflagellar transport 74). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ift-74 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 9

Sequence:: Chromosome: II; NC_003280.10 (6680024..6683544)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C18H9.8 (e-PCR)
- UniSTS:306564

C18H9.4 (e-PCR)
- UniSTS:308614

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables beta-tubulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables beta-tubulin binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cilium assembly	IEA Inferred from Electronic Annotation more info
involved_in detection of stimulus involved in sensory perception	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intraciliary transport	IEA Inferred from Electronic Annotation more info
involved_in intraciliary transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intraciliary transport involved in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cilium	IBA Inferred from Biological aspect of Ancestor more info
part_of intraciliary transport particle B	IBA Inferred from Biological aspect of Ancestor more info
part_of intraciliary transport particle B	IEA Inferred from Electronic Annotation more info
located_in non-motile cilium	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Intraflagellar transport protein 74 homolog

NP_001343748.1

Confirmed by transcript evidence

NP_495359.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

6680024..6683544

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_062958.6 → NP_495359.2 Intraflagellar transport protein 74 homolog [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2C9C2L6, Q7M3L0

Conserved Domains (2) summary

cl25732
Location:265 → 583

SMC_N; RecF/RecN/SMC N terminal domain

cl27975
Location:2 → 113

EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)
NM_001356863.3 → NP_001343748.1 Intraflagellar transport protein 74 homolog [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2C9C2S9, Q7M3L0

Conserved Domains (2) summary

pfam06346
Location:8 → 75

Drf_FH1; Formin Homology Region 1

cl25732
Location:220 → 538

SMC_N; RecF/RecN/SMC N terminal domain