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    tofu-2 Schlafen-like protein 2 [ Caenorhabditis elegans ]

    Gene ID: 179089, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tofu-2
    Official Full Name
    Schlafen-like protein 2
    Primary source
    WormBase:WBGene00017620
    Locus tag
    CELE_F20A1.9
    See related
    AllianceGenome:WB:WBGene00017620
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables RNA endonuclease activity. Involved in primary piRNA processing. Located in cytoplasm. Part of endoribonuclease complex. Is expressed in germ line. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tofu-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    8
    Sequence:
    Chromosome: V; NC_003283.11 (7049434..7051248, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene Secreted protein Neighboring gene Secreted protein Neighboring gene transcellular chaperone signaling (x)cross tissue

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. piRNA processing by a trimeric Schlafen-domain nuclease. Podvalnaya N, et al. Nature, 2023 Oct. PMID 37758951, Free PMC Article
    2. Functional Proteomics Identifies a PICS Complex Required for piRNA Maturation and Chromosome Segregation. Zeng C, et al. Cell Rep, 2019 Jun 18. PMID 31216475
    3. A genome-wide RNAi screen identifies factors required for distinct stages of C. elegans piRNA biogenesis. Goh WS, et al. Genes Dev, 2014 Apr 1. PMID 24696458, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in primary piRNA processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of endoribonuclease complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Schlafen-like protein 2
    NP_504786.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      7049434..7051248 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072385.7 → NP_504786.2  Schlafen-like protein 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504786.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q19614
      Conserved Domains (2) summary
      cd12873
      Location:11 → 167
      SPRY_DDX1; SPRY domain associated with DEAD box gene DDX1
      pfam04326
      Location:231 → 322
      AlbA_2; Putative DNA-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q19614.3

    Gene LinkOut

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